现代肿瘤医学
現代腫瘤醫學
현대종류의학
JOURNAL OF MODERN ONCOLOGY
2014年
6期
1242-1244
,共3页
姜黄素%急性肺动脉栓塞%急性肺损伤%CFTR
薑黃素%急性肺動脈栓塞%急性肺損傷%CFTR
강황소%급성폐동맥전새%급성폐손상%CFTR
curcumin%acute pulmonary embolism%acute lung injury%CFTR
目的：观察姜黄素对急性肺栓塞大鼠肺损伤的保护作用及对CFTR表达的影响。方法：大鼠分为假手术组，模型组，姜黄素（150mg/kg）﹢APE组。制备左肺动脉结扎模拟急性肺动脉栓塞模型。进行血气分析，检测AFC及肺湿干比，real-time PCR方法检测肺组织的CFTR的表达。结果：与模型组比较，姜黄素升高PaO2水平，减轻AFC下降趋势，及减少肺湿干比的增加。姜黄素能提高肺组织的CFTR的表达。结论：姜黄素对急性肺动脉栓塞大鼠的急性肺损伤有保护作用，并上调CFTR的表达。
目的：觀察薑黃素對急性肺栓塞大鼠肺損傷的保護作用及對CFTR錶達的影響。方法：大鼠分為假手術組，模型組，薑黃素（150mg/kg）﹢APE組。製備左肺動脈結扎模擬急性肺動脈栓塞模型。進行血氣分析，檢測AFC及肺濕榦比，real-time PCR方法檢測肺組織的CFTR的錶達。結果：與模型組比較，薑黃素升高PaO2水平，減輕AFC下降趨勢，及減少肺濕榦比的增加。薑黃素能提高肺組織的CFTR的錶達。結論：薑黃素對急性肺動脈栓塞大鼠的急性肺損傷有保護作用，併上調CFTR的錶達。
목적：관찰강황소대급성폐전새대서폐손상적보호작용급대CFTR표체적영향。방법：대서분위가수술조，모형조，강황소（150mg/kg）﹢APE조。제비좌폐동맥결찰모의급성폐동맥전새모형。진행혈기분석，검측AFC급폐습간비，real-time PCR방법검측폐조직적CFTR적표체。결과：여모형조비교，강황소승고PaO2수평，감경AFC하강추세，급감소폐습간비적증가。강황소능제고폐조직적CFTR적표체。결론：강황소대급성폐동맥전새대서적급성폐손상유보호작용，병상조CFTR적표체。
Objective:To observe whether the curcumin could protect the acute lung injury by acute lung embolism and affect the expression of CFTR. Methods:SPF rats were divided into 3 groups:sham group,acute pulmonary em-bolism(APE)group and curcumin group(150mg/kg). The model of acute pulmonary embolism was ligatured the left artery. Blood gas analysis,AFC and wet-to-dry ratio and CFTR mRNA expression were observed. Results:Curcu-min could increase artery O2 pressure,decrease the AFC downward and wet-to-dry ratio. Curcumin could increase the expression of CFTR mRNA. Conculsion:Curcumin could protect the acute lung injury by APE and associated with upward of CFTR mRNA.
