天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2014年
6期
613-615
,共3页
陈绘丽%孙跃民%王雪春%司权%姚薇
陳繪麗%孫躍民%王雪春%司權%姚薇
진회려%손약민%왕설춘%사권%요미
高同种半胱氨酸血症%高血压%Logistic模型
高同種半胱氨痠血癥%高血壓%Logistic模型
고동충반광안산혈증%고혈압%Logistic모형
hyperhomocysteinemia%hypertension%logistic models
目的：调查天津市中老年非高血压人群血浆同型半胱氨酸（Hcy）水平及高同型半胱氨酸血症（hHcy, Hcy≥15μmol/L）患病的影响因素。方法采用自然抽样方法，于2011年5月-2012年12月对天津市内六区非高血压居民进行调查，循环酶法检测血浆Hcy，Logistic回归分析hHcy患病的相关因素。结果共入选874例，平均年龄（57±6）岁，男性25.5%，血浆Hcy水平为12.0μmol/L，hHcy患病为25.2%。多变量Logistic回归分析中，年龄、男性、吸烟、体育锻炼对应的hHcy患病OR（95%CI；P）分别为1.048（1.015~1.083；P=0.004）、4.191（2.359~7.448；P<0.001）、1.280（0.896~1.829；P=0.175）、0.460（0.259~0.816；P=0.008），蔬菜水果摄入量为250~500 g/d、>500 g/d与<250 g/d相比，hHcy患病OR（95%CI；P）分别为0.290（0.179~0.469；P<0.001）、0.168（0.092~0.309；P<0.001）。结论男性、年龄是hHcy患病的危险因素，蔬菜水果摄入量、体育锻炼是保护因素。
目的：調查天津市中老年非高血壓人群血漿同型半胱氨痠（Hcy）水平及高同型半胱氨痠血癥（hHcy, Hcy≥15μmol/L）患病的影響因素。方法採用自然抽樣方法，于2011年5月-2012年12月對天津市內六區非高血壓居民進行調查，循環酶法檢測血漿Hcy，Logistic迴歸分析hHcy患病的相關因素。結果共入選874例，平均年齡（57±6）歲，男性25.5%，血漿Hcy水平為12.0μmol/L，hHcy患病為25.2%。多變量Logistic迴歸分析中，年齡、男性、吸煙、體育鍛煉對應的hHcy患病OR（95%CI；P）分彆為1.048（1.015~1.083；P=0.004）、4.191（2.359~7.448；P<0.001）、1.280（0.896~1.829；P=0.175）、0.460（0.259~0.816；P=0.008），蔬菜水果攝入量為250~500 g/d、>500 g/d與<250 g/d相比，hHcy患病OR（95%CI；P）分彆為0.290（0.179~0.469；P<0.001）、0.168（0.092~0.309；P<0.001）。結論男性、年齡是hHcy患病的危險因素，蔬菜水果攝入量、體育鍛煉是保護因素。
목적：조사천진시중노년비고혈압인군혈장동형반광안산（Hcy）수평급고동형반광안산혈증（hHcy, Hcy≥15μmol/L）환병적영향인소。방법채용자연추양방법，우2011년5월-2012년12월대천진시내륙구비고혈압거민진행조사，순배매법검측혈장Hcy，Logistic회귀분석hHcy환병적상관인소。결과공입선874례，평균년령（57±6）세，남성25.5%，혈장Hcy수평위12.0μmol/L，hHcy환병위25.2%。다변량Logistic회귀분석중，년령、남성、흡연、체육단련대응적hHcy환병OR（95%CI；P）분별위1.048（1.015~1.083；P=0.004）、4.191（2.359~7.448；P<0.001）、1.280（0.896~1.829；P=0.175）、0.460（0.259~0.816；P=0.008），소채수과섭입량위250~500 g/d、>500 g/d여<250 g/d상비，hHcy환병OR（95%CI；P）분별위0.290（0.179~0.469；P<0.001）、0.168（0.092~0.309；P<0.001）。결론남성、년령시hHcy환병적위험인소，소채수과섭입량、체육단련시보호인소。
Objective To investigate the concentration of homocysteine (Hcy) and related factors of hyperhomocyste-inemia (hHcy,Hcy≥15μmol/L) among non-hypertensive people aged between 40-70 in Tianjin. Methods Non-hyperten-sive community residents aged 40-70 years were enrolled randomly from May 2011 to December 2012 in six districts in Tian-jin. Plasma Hcy was assessed by enzyme cycling method. Factors related to hHcy were analyzed in multivariate logistic re-gression models. Results Our study included 874 participants (mean age is 57 ± 6 years, 25.5%of all are males) and the con-centration of Hcy was 12.0 μmol/L. The OR (odds ratio)(95%CI; P)for hHcy were 1.048(1.015,1.083; P=0.004), 4.191 (2.359,7.448;P<0.001), 1.280(0.896,1.829;P=0.175), 0.460(0.259,0.816;P=0.008)respectively for age, male, smoking, exercise, and the odd ratio for hHcy were 0.290(0.179, 0.469;P<0.001), 0.168(0.092,0.309;P<0.001)for consumption of vegetable and fruits 250-500 g/d and>500g/d, compared with<250 g/d. Conclusion Male and age were adverse factors for hHcy, consumption of vegetable and fruits, and exercise were positive factors.
