CAJ | 학술논문

目的：观察当归四逆汤加味联合小牛血清去蛋白注射液治疗痛性糖尿病神经病变（ PDN）的临床疗效。方法将86例PDN患者随机分为2组。2组均予常规糖尿病治疗方法，治疗组44例应用当归四逆汤加味联合小牛血清去蛋白注射液治疗，对照组42例应用硫辛酸注射液治疗。观察2组治疗前后视觉模拟评分（VAS）变化，比较2组疗效，观察2组治疗前后血脂指标[甘油三酯（TG）、总胆固醇（TC）]、凝血功能指标[凝血酶原时间（ PT）、纤维蛋白原（ FIB）]变化。结果2组治疗后VAS评分均较本组治疗前降低（ P＜0．05），且治疗组降低更明显（P＜0．05）。2组总有效率比较差异无统计学意义（P＞0．05）。治疗组治疗后TG、TC均较本组治疗前、对照组治疗后降低（P＜0．05），PT升高（P＜0．05）。结论当归四逆汤加味联合小牛血清去蛋白注射液治疗PDN疗效确切。
목적：관찰당귀사역탕가미연합소우혈청거단백주사액치료통성당뇨병신경병변（ PDN）적림상료효。방법장86례PDN환자수궤분위2조。2조균여상규당뇨병치료방법，치료조44례응용당귀사역탕가미연합소우혈청거단백주사액치료，대조조42례응용류신산주사액치료。관찰2조치료전후시각모의평분（VAS）변화，비교2조료효，관찰2조치료전후혈지지표[감유삼지（TG）、총담고순（TC）]、응혈공능지표[응혈매원시간（ PT）、섬유단백원（ FIB）]변화。결과2조치료후VAS평분균교본조치료전강저（ P＜0．05），차치료조강저경명현（P＜0．05）。2조총유효솔비교차이무통계학의의（P＞0．05）。치료조치료후TG、TC균교본조치료전、대조조치료후강저（P＜0．05），PT승고（P＜0．05）。결론당귀사역탕가미연합소우혈청거단백주사액치료PDN료효학절。
Objective To investigate the clinical effect of combination of Danggui Sini Decoction and depro -teinized calf blood Serum Injection on the treatment of diabetic painful neuropathy ( PDN) .Methods 86 PDN pa-tients were randomly divided into treatment group and control group .The treatment group ( n=44 ) received combina-tion of Danggui Sini Decoction and deproteinized calf blood Serum Injection in the foundation treatment of diabetes mellitus.Control group (n=42) received lipoic acid treatment in the foundation treatment of diabetes mellitus .The changes of VAS score , curative effect , TG, TC, PT and FIB before and after treatment were observed and compared in two groups .Result VAS score after treatment was decreased as compared with that before treatment in two groups (P<0.05).The decrease in treatment group was more obvious (P<0.05).TG and TC after treatment in treatment group were lower than those before treatment in treatment group and after treatment in control group (P<0.05).PT level was increased (P<0.05).Conclusion Danggui Sini Decoction and deproteinized calf blood Serum Injection has definite effect on the treatment of PDN .It was worth of clinical promotion .