CAJ | 학술논문

收集胃食管反流病( GERD)患者189例，其中反流性食管炎( RE)患者56例，非糜烂性反流病( NERD)患者133例，以347例健康体检者作为对照组。 GERD组及对照组填写反流性疾病问卷( RDQ )、综合医院焦虑抑郁量表(HADS)、匹茨堡睡眠质量指数表(PSQI)。 GERD患者接受埃索美拉唑40 mg/d治疗2周。结果显示GERD组焦虑抑郁状态及睡眠障碍的发生率高于对照组( P<0．05)；RE患者与NERD患者焦虑抑郁状态及睡眠障碍的发生率差异无统计学意义( P>0．05)。 GERD患者焦虑抑郁状态、睡眠障碍与症状严重程度呈正相关。单因素Logistic回归分析显示女性、NERD、焦虑抑郁状态是质子泵抑制剂( PPI)疗效的影响因素，多因素Logistic回归分析显示女性、NERD是PPI疗效的独立预测因素。
수집위식관반류병( GERD)환자189례，기중반류성식관염( RE)환자56례，비미란성반류병( NERD)환자133례，이347례건강체검자작위대조조。 GERD조급대조조전사반류성질병문권( RDQ )、종합의원초필억욱량표(HADS)、필자보수면질량지수표(PSQI)。 GERD환자접수애색미랍서40 mg/d치료2주。결과현시GERD조초필억욱상태급수면장애적발생솔고우대조조( P<0．05)；RE환자여NERD환자초필억욱상태급수면장애적발생솔차이무통계학의의( P>0．05)。 GERD환자초필억욱상태、수면장애여증상엄중정도정정상관。단인소Logistic회귀분석현시녀성、NERD、초필억욱상태시질자빙억제제( PPI)료효적영향인소，다인소Logistic회귀분석현시녀성、NERD시PPI료효적독립예측인소。
Reflux disease questionnaire ( RDQ ) , hospital anxiety and depression scale ( HADS ) and Pittsburgh sleep quality index ( PSQI ) were filled out by 189 gastroesophageal reflux disease ( GERD ) patients and 347 healthy subjects. The GERD patients were divided into 56 reflux esophagitis( RE) patients and 133 non-erosive re-flux disease( NERD) patients. GERD patients were treated with esomeprazole 40 mg/d for 2 weeks. The proportion of anxiety, depression and sleep disorder in GERD patients was significantly higher than that in healthy subjects( P<0. 05). There was no difference between RE patients and NERD patients in the proportion of anxiety, depression and sleep disorder(P>0. 05). Anxiety, depression and sleep disorder of GERD patients were positively correlated with the severity of symptoms. Single logistic regression analysis showed that female, NERD, anxiety and depres-sion were risk factors of the efficacy of proton pump inhibitors ( PPI) . Multivariable logistic regression showed that NERD and female were independent predictors of the efficacy of PPI.