CAJ | 학술논문

基于弹性网络模型的热力学方法，识别出麦芽糖转运蛋白质体系中的关键残基，探讨了麦芽糖转运蛋白内长程协同效应，研究结果有助于更好地理解该转运体系发挥生物学功能的分子机制。
기우탄성망락모형적열역학방법，식별출맥아당전운단백질체계중적관건잔기，탐토료맥아당전운단백내장정협동효응，연구결과유조우경호지리해해전운체계발휘생물학공능적분자궤제。
Maltose transporter is an important kind of transmembrane transporters with significant biological functions which bears the transportation of intracellular and extracellular maltose molecules. The transport process of maltose molecule accompanies with large scale cooperative motions between different domains of maltose transporter. And these motions involve some key residues that mediate signal transduction and allosteric effects between different regions of the protein. In this study, we identified the key residues in this protein system with the thermodynamic method based on the elastic network model which was developed by our group. On this basis, we explored the long-range synergies within the maltose transporter. These results are helpful to a better understanding the molecular mechanisms of function of transporters.