CAJ | 학술논문

Wnt/β-catenin信号通路与肿瘤有着密切的关系，此通路的异常活化参与人类多种癌症的发病过程。肝细胞癌（hepatocellular carcinoma, HCC）在全球肿瘤中死亡率位居第3，但其发生发展的分子机制仍不清楚。目前，研究表明Wnt/β-catenin信号通路及其他相互作用信号通路，以及乙型肝炎病毒、丙型肝炎病毒相互作用蛋白等共同在HCC的发生发展过程中起着关键作用，因而，揭示该信号通路在HCC中的作用可为其早期诊断、治疗以及预后提供理论基础。现对Wnt/β-catenin信号通路在HCC中的作用及目前研究状况作一简要综述。
Wnt/β-catenin신호통로여종류유착밀절적관계，차통로적이상활화삼여인류다충암증적발병과정。간세포암（hepatocellular carcinoma, HCC）재전구종류중사망솔위거제3，단기발생발전적분자궤제잉불청초。목전，연구표명Wnt/β-catenin신호통로급기타상호작용신호통로，이급을형간염병독、병형간염병독상호작용단백등공동재HCC적발생발전과정중기착관건작용，인이，게시해신호통로재HCC중적작용가위기조기진단、치료이급예후제공이론기출。현대Wnt/β-catenin신호통로재HCC중적작용급목전연구상황작일간요종술。
Wnt/β-catenin signaling pathway has a close relationship with cancer and is abnormally activated in many human cancers. Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide, but the molecular mechanisms of HCC are still poorly understood. Current studies indicate that Wnt/β-catenin signaling pathway plays a key role in the development and progression of HCC. Validating the role and mechanism of Wnt/β-catenin signaling pathway in HCC will provide a theoretical basis for early diagnosis and treatment of HCC. In this review, we summarize the role of Wnt/β-catenin signaling pathway in HCC and the progress of current researches.