中国现代药物应用
中國現代藥物應用
중국현대약물응용
CHINESE JOURNAL OF MODERN DRUG APPLICATION
2014年
11期
34-35
,共2页
难治性抑郁%帕罗西汀%喹硫平%利培酮%汉密尔顿抑郁量表%副反应量表
難治性抑鬱%帕囉西汀%喹硫平%利培酮%漢密爾頓抑鬱量錶%副反應量錶
난치성억욱%파라서정%규류평%리배동%한밀이돈억욱량표%부반응량표
Refractory depression%Paroxetine%Quetiapine%Risperidone%Hamilton Depression Scale%Treatment Emergent Symptom Scale
目的：探讨帕罗西汀合并喹硫平或利培酮治疗难治性抑郁的疗效比较。方法选择120例难治性抑郁患者，随机分为观察组和对照组。观察组给予帕罗西汀联合喹硫平治疗，对照组给予帕罗西汀联合利培酮治疗。采用汉密尔顿抑郁量表对两组患者治疗前和治疗后的症状进行评定，比较其减分情况；采用副反应量表比较两组患者治疗过程中副反应发生情况并进行比较。结果观察组治疗后的第2周、第4周和第6周汉密尔顿抑郁量表评分与对照组同期比较，得分均低于对照组，差异有统计学意义(P<0.05)。观察组患者治疗过程中不良反应发生率为5.0%；对照组患者治疗过程中不良反应发生率为18.3%；对照组不良反应发生率高于观察组，差异有统计学意义(P<0.05)。结论帕罗西汀联合喹硫平治疗难治性抑郁临床疗效显著优于帕罗西汀联合利培酮治疗组，不良反应少，可作为难治性抑郁症优化治疗方案之一。
目的：探討帕囉西汀閤併喹硫平或利培酮治療難治性抑鬱的療效比較。方法選擇120例難治性抑鬱患者，隨機分為觀察組和對照組。觀察組給予帕囉西汀聯閤喹硫平治療，對照組給予帕囉西汀聯閤利培酮治療。採用漢密爾頓抑鬱量錶對兩組患者治療前和治療後的癥狀進行評定，比較其減分情況；採用副反應量錶比較兩組患者治療過程中副反應髮生情況併進行比較。結果觀察組治療後的第2週、第4週和第6週漢密爾頓抑鬱量錶評分與對照組同期比較，得分均低于對照組，差異有統計學意義(P<0.05)。觀察組患者治療過程中不良反應髮生率為5.0%；對照組患者治療過程中不良反應髮生率為18.3%；對照組不良反應髮生率高于觀察組，差異有統計學意義(P<0.05)。結論帕囉西汀聯閤喹硫平治療難治性抑鬱臨床療效顯著優于帕囉西汀聯閤利培酮治療組，不良反應少，可作為難治性抑鬱癥優化治療方案之一。
목적：탐토파라서정합병규류평혹리배동치료난치성억욱적료효비교。방법선택120례난치성억욱환자，수궤분위관찰조화대조조。관찰조급여파라서정연합규류평치료，대조조급여파라서정연합리배동치료。채용한밀이돈억욱량표대량조환자치료전화치료후적증상진행평정，비교기감분정황；채용부반응량표비교량조환자치료과정중부반응발생정황병진행비교。결과관찰조치료후적제2주、제4주화제6주한밀이돈억욱량표평분여대조조동기비교，득분균저우대조조，차이유통계학의의(P<0.05)。관찰조환자치료과정중불량반응발생솔위5.0%；대조조환자치료과정중불량반응발생솔위18.3%；대조조불량반응발생솔고우관찰조，차이유통계학의의(P<0.05)。결론파라서정연합규류평치료난치성억욱림상료효현저우우파라서정연합리배동치료조，불량반응소，가작위난치성억욱증우화치료방안지일。
Objective To explore the efficacy of paroxetine combined with quetiapine or risperidone in treatment-refractory depression. Methods 120 patients with refractory depression were selected and randomly divided into observation group and control group. The observation group was given paroxetine combined with quetiapine while the control group was given paroxetine combined with risperidone, the Hamilton Depression Scale (HAMD)was used in the two groups of patients before and after treatment, and Treatment Emergent Symptom Scale(TESS) was used to measure the adverse reaction of the treatment. Results Hamilton Depression Scale scores were lower in the observation group after treatment of second weeks, fourth weeks and sixth weeks compared with those in the control group, the difference was statistically significant (P<0.05). The occurrence rate of adverse reaction in the observation group during treatment was 5%; the rate of adverse reactionin the control group during treatment was 18.3%;the adverse reaction rate in the control group was higher than that in the observation group, and the difference was statistically significant (P<0.05). Conclusion Effect of paroxetine combined with quetiapine in refractory depression is better than combined with risperidone, which has lower occurrence rate of adverse reaction as well and and could be one valuable augmentation in refractory depression.
