CAJ | 학술논문

目的：观察傣医验方“傣痛消”对急性高尿酸血症小鼠UA、BUN、XOD的影响并探讨其作用机理。方法：通过酵母膏灌胃复制高尿酸血症动物模型，以“傣痛消”、别嘌呤醇、苯溴马隆干预，检测血清尿酸（UA）、尿素氮（BUN）、黄嘌呤氧化酶（XOD）的水平。结果：傣痛消高、中、低剂量、别嘌呤醇均能显著降低小鼠血UA水平（P＜0.01）；傣痛消高、中、低剂量、苯溴马隆均能显著降低高尿酸血症小鼠BUN浓度（P＜0.01）；傣痛消高、中、低剂量、别嘌醇均能抑制高尿酸血症小鼠血X0D活性（P＜0.01）。结论：傣痛消高、中、低剂量均能降低小鼠血UA水平、BUN浓度以及抑制高尿酸血症小鼠血XOD活性，对高尿酸血症小鼠具有良好的保护作用，其作用机理可能与抑制黄嘌呤氧化酶活性有关。
목적：관찰태의험방“태통소”대급성고뇨산혈증소서UA、BUN、XOD적영향병탐토기작용궤리。방법：통과효모고관위복제고뇨산혈증동물모형，이“태통소”、별표령순、분추마륭간예，검측혈청뇨산（UA）、뇨소담（BUN）、황표령양화매（XOD）적수평。결과：태통소고、중、저제량、별표령순균능현저강저소서혈UA수평（P＜0.01）；태통소고、중、저제량、분추마륭균능현저강저고뇨산혈증소서BUN농도（P＜0.01）；태통소고、중、저제량、별표순균능억제고뇨산혈증소서혈X0D활성（P＜0.01）。결론：태통소고、중、저제량균능강저소서혈UA수평、BUN농도이급억제고뇨산혈증소서혈XOD활성，대고뇨산혈증소서구유량호적보호작용，기작용궤리가능여억제황표령양화매활성유관。
Objective To investigate the effect of Daitongxiao on blood uric acid and blood urea nitrogen of mice with acute hype-ruricemia.Methods The mice were divided into normal,model,allopurinol (positive control,40 mg/kg),Benzbromarone (positive control,20 mg/kg),low-,mid-,and high-dose (260,780,and 2340mg/kg)DTX groups.Except the model group,mice in other groups were administered yeast (3000mg/kg)once daily for 7d.Positive control were administered allopurinol (40mg/kg)once daily for 4d since the 7thday.Other low-,mid-,and high-dose (260,780,and 2340mg/kg)DTX groups were administered since the 4thday for 4days.The blood uric acid and blood urea nitrogen were determined after the last administration.Result Com-pared with the model group,DTX at mid-and high-dose could obviously decreased the blood uric acid level in mice (P<0.01),so did allopurinol (P<0.01).DTX at low-and mid-dose could obviously decrease the blood urea nitrogen level in mice (P<0.01) Conclusion DTX could inhibit the increase of blood uric acid and blood urea nitrogen in mice with acute hyperuricemia and Its mecha-nism may be related to inhibit xanthine oxidase activity.