CAJ | 학술논문

目的：探讨盐酸戊乙奎醚对体外循环（CPB）后IL-6和IL-10的影响。方法：选择ASAⅡ～Ⅲ级择期CPB下行心脏瓣膜置换手术患者40例，随机分为两组（n＝20）：盐酸戊乙奎醚（P）组和对照(C)组。分别在麻醉诱导后CPB前5min，P组静注PHC 0.1mg/kg，C组静注等量生理盐水。两组分别于麻醉前（T0）、主动脉阻断5 min（T1）、CPB结束(T2)、术后48h（T3）和术后1W（T4）抽血ELISA法测定IL-6和IL-10的浓度。结果：与T0比较，两组在T1～T4两指标均升高；与C组比较，P组的IL-6在T1～T3时下降、IL-10在T1～T4升高（P＜0.05）。结论：盐酸戊乙奎醚可减轻CPB后的炎性反应，增强抗炎作用。
목적：탐토염산무을규미대체외순배（CPB）후IL-6화IL-10적영향。방법：선택ASAⅡ～Ⅲ급택기CPB하행심장판막치환수술환자40례，수궤분위량조（n＝20）：염산무을규미（P）조화대조(C)조。분별재마취유도후CPB전5min，P조정주PHC 0.1mg/kg，C조정주등량생리염수。량조분별우마취전（T0）、주동맥조단5 min（T1）、CPB결속(T2)、술후48h（T3）화술후1W（T4）추혈ELISA법측정IL-6화IL-10적농도。결과：여T0비교，량조재T1～T4량지표균승고；여C조비교，P조적IL-6재T1～T3시하강、IL-10재T1～T4승고（P＜0.05）。결론：염산무을규미가감경CPB후적염성반응，증강항염작용。
Objective To investigate the effects of penehyclidine hydrochloride on IL-6 and IL-10 induced by cardiopulmonary bypass (CPB) .Methods Forty patients undergoing valve replacement with CPB were randomly divided into two groups(n=20): group PHC and group C. Pnehyclidine hydrochloride 0.1mg/kg was injected intravenously before 5min CPB.Blood samples were colected for IL-6 and IL-10 before CPB (T0),after 5min aorta block(T1),CPB cease(T2)and 48h (T3)and 1w(T4) after the operation .Results The levels of IL-6 was significantly lower and IL-10 was significantly higher in group P at T1~T3 than those in group C(P<0.05). Conclusion Penehyclidine hydrochloride could inhibit inflammatory response induced by cardiopulmonary bypass and may be helpful in preventing the systemic inflammatory response .