CAJ | 학술논문

目的：研究磷酸奥司他韦治疗甲型H1N1流感的临床疗效及其安全性。方法采用回顾性分析方法，对我院527例使用磷酸奥司他韦的住院患者进行综合分析。结果527例甲型H1N1流感患者中，普通型376例，重症76例，危重症75例，与发病48h后比较，48h内使用奥司他韦治疗的普通型及重症患者发热持续时间、临床症状持续时间和病毒核酸阳性持续时间明显减少，危重症患者的发热持续时间、病毒核酸阳性持续时间都明显减少，而临床症状缓解时间两组无明显差异。不同治疗时间对患者的住院时间无明显影响。普通型、重症患者均无死亡病例，危重症患者48h内与48h后治疗的死亡率无显著性差异。527例患者中不良反应20例，主要为消化系统症状。结论磷酸奥司他韦治疗甲型H1N1流感安全有效，发病48h内使用，能有效减轻病情，缩短病程。
목적：연구린산오사타위치료갑형H1N1류감적림상료효급기안전성。방법채용회고성분석방법，대아원527례사용린산오사타위적주원환자진행종합분석。결과527례갑형H1N1류감환자중，보통형376례，중증76례，위중증75례，여발병48h후비교，48h내사용오사타위치료적보통형급중증환자발열지속시간、림상증상지속시간화병독핵산양성지속시간명현감소，위중증환자적발열지속시간、병독핵산양성지속시간도명현감소，이림상증상완해시간량조무명현차이。불동치료시간대환자적주원시간무명현영향。보통형、중증환자균무사망병례，위중증환자48h내여48h후치료적사망솔무현저성차이。527례환자중불량반응20례，주요위소화계통증상。결론린산오사타위치료갑형H1N1류감안전유효，발병48h내사용，능유효감경병정，축단병정。
Objective To Study the cinical efficacy and safety of oseltamivir in the treatment of Pandemic(H1N1).Methods The clinical data of 527 patients who were admitted into Beijing DiTan Hospital from 2009 to 2013 were analyzed retrospective.Results The 527 cases were dicided into 3 groups according to the severity of the clinical symptoms:common type,severe type and extremely severe type. Compared with patients therapied after 48 hours,duration of clinical symptoms,duration of fever and duration of viral nucleic acid positive were significant decrease in common type and severe type patients with oseltamivir within 48 hours.Duration of fever and duration of viral nucleic acid positive were also significant decrease in extremely severe type patients,but duration of clinical symptoms was not significant difference.Hospitalization time in the three groups were not statistically significant.There were no dead cases in common type and severe type patients.The difference of mortality rate in extremely severe type patients with oseltamivir in different time was not significant.Adverse drug reactions of 20 cases mainly occurred in digestive system. Conclusion Osehamivir was effective and safety in the treatment of Pandemic(H1N1 ).Therapiy with oseltamivir in 48 hours would effectively ameliorate the symptomsand shorten the course of the disease.