CAJ | 학술논문

目的研究老年人微观肠炎临床特点及美沙拉嗪短期治疗效果. 方法选择2011年1-12月长治和平医院诊断为微观肠炎的老年患者116例,分析其临床表现、微观肠炎相关药物服用状况、病理分型及美沙拉嗪短期治疗效果. 结果老年人微观肠炎占同期老年慢性腹泻患者27.6％,临床表现轻中度水样、黏液便,伴重度腹痛者仅占1.7％.胶原性肠炎与淋巴细胞肠炎型分别为31.9％与68.1％,约50.0％患者有服用微观肠炎相关药物史；美沙拉嗪治疗4周后,胶原性肠炎组有效率为64.9％,淋巴细胞肠炎组为84.8％,差异有统计学意义(x2=5.929,P=0.015)；淋巴细胞肠炎组治疗有效率与病理缓解相关(x2=5.896,P=0.015)；停药8周后,两组复发率分别为45.8％与34.3％(x2=0.999,P=0.317). 结论微观肠炎可能是老年慢性腹泻患者主要病因之一,美沙拉嗪治疗老年微观肠炎患者近期疗效较好,但长期维持治疗仍需进一步观察.
목적 연구노년인미관장염림상특점급미사랍진단기치료효과. 방법 선택2011년1-12월장치화평의원진단위미관장염적노년환자116례,분석기림상표현、미관장염상관약물복용상황、병리분형급미사랍진단기치료효과. 결과 노년인미관장염점동기노년만성복사환자27.6％,림상표현경중도수양、점액편,반중도복통자부점1.7％.효원성장염여림파세포장염형분별위31.9％여68.1％,약50.0％환자유복용미관장염상관약물사；미사랍진치료4주후,효원성장염조유효솔위64.9％,림파세포장염조위84.8％,차이유통계학의의(x2=5.929,P=0.015)；림파세포장염조치료유효솔여병리완해상관(x2=5.896,P=0.015)；정약8주후,량조복발솔분별위45.8％여34.3％(x2=0.999,P=0.317). 결론 미관장염가능시노년만성복사환자주요병인지일,미사랍진치료노년미관장염환자근기료효교호,단장기유지치료잉수진일보관찰.
Objective To investigate clinical features of microscopic colitis (MC) in the elderly and short-term effect of mesalamine on MC.Methods Totally 116 elderly patients with MC in our hospital were recruited from January 2011 to December 2011.Clinical manifestations,use of MC related drugs (MCRDs),pathological classifications and short-term effect of mesalazine were collected and analyzed.Results MC patients accounted for 27.6 ％ in elderly patients with chronic diarrhea,who presented with mild to middle watery or mucous stool,and only 1.7％ of MC patients accompanied with severe stomach pain.Collagenous colitis (CC) and lymphocytic enteritis (LC) accounted for 31.9％ and 68.1％,respectively in MC patients and 50％ of them had MCRDs taking history.There was a significant difference in short-term effective rate between CC group and LC group at 4 weeks after mesalazine treatment (64.9％ vs.84.8％,x2 =5.929,P=0.015).The effective rate was significantly related with the relief of pathology in LC group (x2 =5.896,P=0.015).The relapse rate had no significant difference between CC group and LC group at 8 weeks after withdrawal of mesalazine treatment (45.8％ vs.34.3 ％,P =0.317).Conclusions MC may be one of the main reasons leading to chronic diarrhea in the elderly.Mesalazine has a better effect for the short-term treatment of MC in the elderly,but the long-term maintenance therapy still needs further study.