CAJ | 학술논문

目的探讨肝移植术后发生急性排斥反应的诊断方法与治疗原则.方法回顾性分析解放军总医院肝胆外科2007年1月-2010年12月收治的232例肝移植患者的临床资料,对术后33例发生急性排斥反应患者的诊断及治疗方法进行分析.结果 42例患者术后因肝功能异常而行肝脏活检并根据Banff标准诊断,其中33例发生急性排斥反应,28例为单次,5例为两次,急性排斥反应发病率为14.2％.发生急性排斥反应的患者经激素冲击或调整免疫抑制药物剂量后,31例缓解,2例死亡.结论肝脏穿刺活检对于肝移植术后急性排斥反应的诊断有重要意义,免疫抑制药物剂量调整以及激素冲击是治疗急性排斥反应的有效措施.
목적 탐토간이식술후발생급성배척반응적진단방법여치료원칙.방법 회고성분석해방군총의원간담외과2007년1월-2010년12월수치적232례간이식환자적림상자료,대술후33례발생급성배척반응환자적진단급치료방법진행분석.결과 42례환자술후인간공능이상이행간장활검병근거Banff표준진단,기중33례발생급성배척반응,28례위단차,5례위량차,급성배척반응발병솔위14.2％.발생급성배척반응적환자경격소충격혹조정면역억제약물제량후,31례완해,2례사망.결론 간장천자활검대우간이식술후급성배척반응적진단유중요의의,면역억제약물제량조정이급격소충격시치료급성배척반응적유효조시.
Objective To explore the diagnosis and treatment of acute rejection after liver transplantation.Methods Retrospectively analyzed the clinical data of 232 patients after liver transplantation between January 2007and December 2010.Analyzed the diagnosis and treatment methods of 33 patients who were diagnosed of acute rejection.Results There were 42 patients taken biopsy because of graft dysfunction.And 33 patients were diagnosed of acute rejection.There were 28 patients had only one episode of acute rejection,5 patients had two,the incidence of acute rejection was 14.2％.After drug dosage adjustment or steroid intensive therapy,31 patients were cured,and 2 patients died.Conclusions Liver biopsy is important for the diagnosis of acute rejection.The dosage adjustment of immunosuppressor and steroid intensive are the effective therapy to acute rejection.