CAJ | 학술논문

目的：观察腹腔镜下胃旁路术(LRYGB)对非肥胖2型糖尿病患者临床疗效。方法对2011年1月~2012年10月间本院实施LRYGB的2型糖尿病病患者中BMI<28.0 kg/m216例患者的临床资料进行回顾性分析。结果平均手术时间145 min,术中平均出血量35 ml,术后平均9.3 d,术后出现吻合口出血1例,无死亡病例及严重的手术并发症。术后患者1个月空腹血糖及餐后血糖明显下降(P<0.01),术后3个月至半年降至正常水平。糖化血红蛋白在术后3个月开始明显下降(P<0.01),术后半年降至正常水平。体质量指数在术后1个月有明显下降,术后6个月~12个月期间体质量指数趋于稳定,无明显变化。结论LRYGB后2型糖尿病患者血糖代谢明显改善,但其远期疗效还需进一步研究。
목적：관찰복강경하위방로술(LRYGB)대비비반2형당뇨병환자림상료효。방법대2011년1월~2012년10월간본원실시LRYGB적2형당뇨병병환자중BMI<28.0 kg/m216례환자적림상자료진행회고성분석。결과평균수술시간145 min,술중평균출혈량35 ml,술후평균9.3 d,술후출현문합구출혈1례,무사망병례급엄중적수술병발증。술후환자1개월공복혈당급찬후혈당명현하강(P<0.01),술후3개월지반년강지정상수평。당화혈홍단백재술후3개월개시명현하강(P<0.01),술후반년강지정상수평。체질량지수재술후1개월유명현하강,술후6개월~12개월기간체질량지수추우은정,무명현변화。결론LRYGB후2형당뇨병환자혈당대사명현개선,단기원기료효환수진일보연구。
ObjectiveTo evaluate the efficacy of Laparoscopic Roux-en-Y Gastric Bypass(LRYGB) in non-obese patients with type 2 diabetes mellitus.MethodsLRYGB was performed in 16 T2DM patients with BMI<28 kg/m2 in our hospital from January 2011 to October 2012. Preoperative date including BMI, fasting plasma glucose, 2 h postprandial glucose and glycosylated hemoglobin were compared with the date collected at 1,3,6 and 12 postoperative months.ResultsThe mean operative time was 145 min, the mean bleeding was 35 ml, and the mean postoperative time was 9.3 days. Anastomosis bleeding occurred in 1 case. There were no mortality and significant surgical complications occurred. Both fasting plasma glucose and 2 h postprandial glucose were significantly decreased at 1 month after operation, and the changes were lasted for 12 month. Significant reduction in glycosylated hemoglobin from 3 months after operation was observed. Glycosylated hemoglobin dropped to normal level from 6 months post-operation. BMI obviously decreased after 1 month, and there was no drop from 6 month comparing with 12 month after operation.ConclusionLRYGB is an effective treatment to non-obese patients with type 2 diabetes mellitus. It has long-term efficacy and needs further research.