CAJ | 학술논문

目的：探讨慢性左心功能不全与细胞TNF、IL-1、IL-6的关系。方法选择2009年8月~2012年2月在我院心内科住院的慢性左心功能不全患者60例作为观察组(II级10例，III级30例，IV级20例)，同期选择在我院进行体检的健康人60例作为对照组，都进行了血清TNF-α、IL-1、IL-6含量的检测。结果观察组患者TNF-α、IL-1和IL-6含量明显高于对照组，差异有统计学意义(P<0.05)。随着心功能分级级别的升高，其TNF-α、IL-1和 IL-6含量也明显升高，组间对比都有明显差异(P<0.05)。结论慢性左心功能不全患者血清中TNF-α、IL-1、IL-6水平明显升高，且随着心功能损害程度加重而升高，呈现正相关。
목적：탐토만성좌심공능불전여세포TNF、IL-1、IL-6적관계。방법선택2009년8월~2012년2월재아원심내과주원적만성좌심공능불전환자60례작위관찰조(II급10례，III급30례，IV급20례)，동기선택재아원진행체검적건강인60례작위대조조，도진행료혈청TNF-α、IL-1、IL-6함량적검측。결과관찰조환자TNF-α、IL-1화IL-6함량명현고우대조조，차이유통계학의의(P<0.05)。수착심공능분급급별적승고，기TNF-α、IL-1화 IL-6함량야명현승고，조간대비도유명현차이(P<0.05)。결론만성좌심공능불전환자혈청중TNF-α、IL-1、IL-6수평명현승고，차수착심공능손해정도가중이승고，정현정상관。
Objective To study the relationship between chronic left ventricular dysfunction and TNF, IL-1 and IL-6. Methods 60 cases of chronic left ventricular dysfunction patients admit ed in the Cardiology Department of our hospital from Aug. 2009 to Feb. 2012 were chosen as the observation group. 60 healthy persons who did the physical examination in our hospital in the same period were chosen as control group. The content of TNF-α, IL-1 and IL-6 in their serum were tested. Results The content of TNF-α, IL-1 and IL-6 in observation group were apparently higher than control group, and the dif erence was statistical y significant (P<0.05). The content of TNF-α, IL-1 and IL-6 increased with the elevation of cardiac function classification level, and the dif erence between each team was statistical y significant (P<0.05). Conclusion The level of TNF-α, IL-1 and IL-6 in chronic left ventricular dysfunction patients were markedly elevated, and it increased with the elevation of cardiac function classification level, which is positive correlation.