CAJ | 학술논문

[目的]探讨对乙酰氨基酚预防唑来膦酸注射液(密固达)不良反应最佳用药时机。[方法]将60例绝经后骨质疏松症病人随机分入观察组和对照组,每组30例。观察组静脉输注唑来膦酸注射液前1 h,对照组在静脉输注后1h给予口服对乙酰氨基酚缓释片,两组间隔6h 后和次日再分别给药1次。用副反应量表(TESS)评定不良反应。[结果]在使用唑来膦酸注射液后4h、8 h和第2日3个评分时段,观察组TESS评分低于对照组(t=-7.087,-4.777和-5.087,P均<0.01)。[结论]在静脉输注唑来膦酸注射液前使用对乙酰氨基酚,能有效预防唑来膦酸不良反应,效果优于静脉输注后给药。
[목적]탐토대을선안기분예방서래련산주사액(밀고체)불량반응최가용약시궤。[방법]장60례절경후골질소송증병인수궤분입관찰조화대조조,매조30례。관찰조정맥수주서래련산주사액전1 h,대조조재정맥수주후1h급여구복대을선안기분완석편,량조간격6h 후화차일재분별급약1차。용부반응량표(TESS)평정불량반응。[결과]재사용서래련산주사액후4h、8 h화제2일3개평분시단,관찰조TESS평분저우대조조(t=-7.087,-4.777화-5.087,P균<0.01)。[결론]재정맥수주서래련산주사액전사용대을선안기분,능유효예방서래련산불량반응,효과우우정맥수주후급약。
Obj ective:To probe into the best medication timing of acetamino-phen for prevention of zoledronic acid adverse reaction.Methods:A total of 60 cases of patients with postmenopausal osteoporosis were randomly divided into observation group and control group,30 cases in each.At 1 h before intrave-nous infusion of zoledronic acid inj ection in observation group and at 1 h after intravenous infusion in control group,the patients were given oral acetamino-phen sustained release tablets,oral acetaminophen were administered once a-gain respectively after interval 6 h and the next day in two groups.The adverse reactions were evaluated with TESS (TESS).Results:three ratings periods in-cluding 4 h,8h and the 2nd day after the use of zoledronic acid injection,the TESS score in observation group was lower than that in control group (t= -7.087,-4.777 and -5.087,P<0.01).Conclusion:acetaminophen used before intravenous infusion of zoledronic acid inj ection using can effectively prevent adverse effects of zoledronic acid,and its effect is better than that after intrave-nous administration.