中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
17期
107-108
,共2页
慢性阻塞性肺疾病%降钙素原%抗生素
慢性阻塞性肺疾病%降鈣素原%抗生素
만성조새성폐질병%강개소원%항생소
Chronic obstructive pulmonary disease%Serum procalcitonin%Antibiotics
目的：探讨血清降钙素原水平测定在慢性阻塞性肺疾病急性加重期(AECOPD)的临床意义。方法：2013年1月-2014年1月收治 AECOPD 患者286例，随机分成观察组和对照组各143例，对照组患者在治疗第1天、4天、7天、10天、14天进行血常规检查，并根据临床症状、体征、实验室检测来判断是否需要应用抗生素治疗。观察组在对照组的基础上增加对血清PCT的检查，根据PCT检查结果确定是否使用抗生素。结果：观察组143例患者PCT阳性103例，阳性率72.0%，hs-CRP 阳性85例，阳性率59.4%，比较差异有统计学意义(P＜0.05)。观察组使用抗生素(8.1±1.9)天，患者住院时间(11.2±19)天，二重感染7例(4.9%)；对照组使用抗生素(22.3±5.7)天，患者住院时间(22.2±7.8)天，二重感染34例(23.8%)，两组比较差异有统计学意义(P＜0.05)。结论：血清降钙素原水平是判断是否使用抗生素的重要指标，对合理使用抗生素有着重要的临床意义。
目的：探討血清降鈣素原水平測定在慢性阻塞性肺疾病急性加重期(AECOPD)的臨床意義。方法：2013年1月-2014年1月收治 AECOPD 患者286例，隨機分成觀察組和對照組各143例，對照組患者在治療第1天、4天、7天、10天、14天進行血常規檢查，併根據臨床癥狀、體徵、實驗室檢測來判斷是否需要應用抗生素治療。觀察組在對照組的基礎上增加對血清PCT的檢查，根據PCT檢查結果確定是否使用抗生素。結果：觀察組143例患者PCT暘性103例，暘性率72.0%，hs-CRP 暘性85例，暘性率59.4%，比較差異有統計學意義(P＜0.05)。觀察組使用抗生素(8.1±1.9)天，患者住院時間(11.2±19)天，二重感染7例(4.9%)；對照組使用抗生素(22.3±5.7)天，患者住院時間(22.2±7.8)天，二重感染34例(23.8%)，兩組比較差異有統計學意義(P＜0.05)。結論：血清降鈣素原水平是判斷是否使用抗生素的重要指標，對閤理使用抗生素有著重要的臨床意義。
목적：탐토혈청강개소원수평측정재만성조새성폐질병급성가중기(AECOPD)적림상의의。방법：2013년1월-2014년1월수치 AECOPD 환자286례，수궤분성관찰조화대조조각143례，대조조환자재치료제1천、4천、7천、10천、14천진행혈상규검사，병근거림상증상、체정、실험실검측래판단시부수요응용항생소치료。관찰조재대조조적기출상증가대혈청PCT적검사，근거PCT검사결과학정시부사용항생소。결과：관찰조143례환자PCT양성103례，양성솔72.0%，hs-CRP 양성85례，양성솔59.4%，비교차이유통계학의의(P＜0.05)。관찰조사용항생소(8.1±1.9)천，환자주원시간(11.2±19)천，이중감염7례(4.9%)；대조조사용항생소(22.3±5.7)천，환자주원시간(22.2±7.8)천，이중감염34례(23.8%)，량조비교차이유통계학의의(P＜0.05)。결론：혈청강개소원수평시판단시부사용항생소적중요지표，대합리사용항생소유착중요적림상의의。
Objective:To investigate the significance of determining serum procalcitonin level in patients with acute exacerbation of chronic obstructive pulmonary disease.Methods:286 cases with AECOPD were selected from January 2013 to January 2014. They were randomly divided into the observation group and the control group with 143 cases in each.The control group were checked blood tests in 1,4,7,10,14 days,and to determine the need for antibiotic treatment according to the clinical symptoms, signs and laboratory test.The observation group were added serum PCT examination based on the control group treatment,and determined whether the use of antibiotics according to the PCT examination results.Results:In 143 cases of the observation group, 103 cases were PCT positive,and the positive rate was 72%.85 cases were hs-CRP positive,and the positive rate was 59.4%.There were significant difference(P<0.05).In the observation group,the average duration of antibiotics use was 8.1±1.9 days,and the hospitalization time was 11.2±19 days,7 cases of double infection,accounting for 4.9%.In the control group,the average duration of antibiotics use was 22.3±5.7 days,and the hospitalization time was 22.2±7.8 days,34 cases of double infection,accounting for 23.8% .There were significant difference between two groups(P<0.05).Conclusion:The level of serum procalcitonin is an important index to assess whether the use of antibiotics,and it has important clinical significance for the rational use of antibiotics.
