医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
17期
638-639
,共2页
支气管哮喘%气道重塑%WISP-1%CCN家族
支氣管哮喘%氣道重塑%WISP-1%CCN傢族
지기관효천%기도중소%WISP-1%CCN가족
Asthma%Airway remoldeling%WISP-1%CCN family
Wnt诱导的分泌型蛋白-1(WISP-1)是CCN家族成员之一。早期的研究已证实其在肿瘤形成和增殖中具有重要作用，其异常表达能促进细胞增殖、介导细胞黏附、刺激细胞转移、促进有丝分裂及细胞外基质的形成等。然而，近年来国内外研究发现，WISP-1的异常表达与哮喘气道重塑也密切相关。在哮喘中，WISP-1高表达可诱导气道平滑肌增生肥大，促进肺成纤维细胞活化和气道上皮下胶原沉积。本文就WISP-1与哮喘气道重塑的研究进展作一综述。
Wnt誘導的分泌型蛋白-1(WISP-1)是CCN傢族成員之一。早期的研究已證實其在腫瘤形成和增殖中具有重要作用，其異常錶達能促進細胞增殖、介導細胞黏附、刺激細胞轉移、促進有絲分裂及細胞外基質的形成等。然而，近年來國內外研究髮現，WISP-1的異常錶達與哮喘氣道重塑也密切相關。在哮喘中，WISP-1高錶達可誘導氣道平滑肌增生肥大，促進肺成纖維細胞活化和氣道上皮下膠原沉積。本文就WISP-1與哮喘氣道重塑的研究進展作一綜述。
Wnt유도적분비형단백-1(WISP-1)시CCN가족성원지일。조기적연구이증실기재종류형성화증식중구유중요작용，기이상표체능촉진세포증식、개도세포점부、자격세포전이、촉진유사분렬급세포외기질적형성등。연이，근년래국내외연구발현，WISP-1적이상표체여효천기도중소야밀절상관。재효천중，WISP-1고표체가유도기도평활기증생비대，촉진폐성섬유세포활화화기도상피하효원침적。본문취WISP-1여효천기도중소적연구진전작일종술。
The WNT1 inducible signaling pathway protein 1 (WISP-1) is a secreted, matricellular protein al ocated to the CCN family. It has been shown that WISP-1 plays an important role in tumorigenesis and tumor growth. Its overexpression is associated with cellproliferation, celladhesion, cellmigration, as wel as extracellular matrix production. Further, recent studies al uded to an possible role of WISP-1 in airway romodeling of asthma. It has been pointed out that the WISP-1 overexpression involves in proliferation of airway smooth muscle cells and lung fibroblasts, inducing extracellular matrix production and subepithelial fibrosis. In this review, we wil present a synopsis of current WISP-1 research with particular at ention paid to the role of WISP-1 in airway remodeling of asthma.
