CAJ | 학술논문

目的：探讨系统性红斑狼疮(SLE)合并肺部真菌感染的病原菌、危险因素、临床症状及预后。方法回顾性分析地方法对我院22例在聊城市人民医院住院的系统性红斑狼疮合并肺部真菌感染患者的病例特点进行分析。结果 SLE合并肺部真菌感染病原菌以白色假丝酵母菌为主，再次为近平滑假丝酵母菌及曲霉菌属感染。真菌感染组以发热、咳嗽、咯痰、胸闷气喘症状为主。原发狼疮性肺炎、长期联合应用抗菌药物、长期大量应用糖皮质激素是继发真菌感染的危险因素。合并肺部真菌感染病死率较高，以曲霉菌感染尤甚。结论系统性红斑狼疮合并肺部真菌感染死亡率高，应引起重视。控制狼疮应合理应用糖皮质激素，积极控制原发病，对合并细菌感染者应合理应用抗菌药物，对真菌感染要做到早期预防，早期诊断，尽早治疗，减少不良预后的发生。
목적：탐토계통성홍반랑창(SLE)합병폐부진균감염적병원균、위험인소、림상증상급예후。방법회고성분석지방법대아원22례재료성시인민의원주원적계통성홍반랑창합병폐부진균감염환자적병례특점진행분석。결과 SLE합병폐부진균감염병원균이백색가사효모균위주，재차위근평활가사효모균급곡매균속감염。진균감염조이발열、해수、각담、흉민기천증상위주。원발랑창성폐염、장기연합응용항균약물、장기대량응용당피질격소시계발진균감염적위험인소。합병폐부진균감염병사솔교고，이곡매균감염우심。결론계통성홍반랑창합병폐부진균감염사망솔고，응인기중시。공제랑창응합리응용당피질격소，적겁공제원발병，대합병세균감염자응합리응용항균약물，대진균감염요주도조기예방，조기진단，진조치료，감소불량예후적발생。
Objective To investigate the systemic lupus erythematosus (SLE) pathogens, risk factors, clinical symptoms and prognosis of patients with pulmonary fungal infection. Methods Retrospective analysis method in our hospital 22 patients hospitalized in the Liaocheng People's Hospital from systemic lupus erythematosus complicated by pulmonary fungal infection cases were analyzed. Results Candida albicans to the main pathogenic bacteria of SLE complicated with pulmonary fungal infection results, again for Candida parapsilosis and Aspergil us infection. Fungal infection group with fever, cough, expectoration, bosom frowsty asthma symptoms. Primary lupus pneumonia, long-term combined application of antibiotics, long-term is a risk factor for fungal infection in the patients with glucocorticoid lots. High mortality of patients with pulmonary fungal infections, especial y with Aspergil us infection. Conclusion Systemic lupus erythematosus pulmonary fungal infections with high mortality, at ention should be paid to. Control of lupus should be reasonable application of glucocorticoids, active control of primary disease, the combined with bacterial infection should be rational use of antimicrobial agents, the fungal infection to do early prevention, early diagnosis, early treatment, reduce adverse outcomes.