CAJ | 학술논문

目的：建立安神类中成药、保健食品中非法添加14种催眠类药物的定性和定量测定方法。方法使用RRLC-Q-TOF-NS作为检测方法，化合物准分子离子峰的保留时间、一级质谱和二级质谱作为定性依据；一级质谱准分子离子峰面积作为定量依据。结果建立安神类中成药、保健食品中非法添加14种催眠类药物的定性和定量检验测定方法，14种成分线性相关系数（ r）均＞0.99，回收率80％~120％。结论 RRLC-Q-TOF-NS法定性准确，干扰少，定量线性及回收率良好，适用于安神类中成药、保健食品非法添加催眠类药品的定性和定量检验。
목적：건립안신류중성약、보건식품중비법첨가14충최면류약물적정성화정량측정방법。방법사용RRLC-Q-TOF-NS작위검측방법，화합물준분자리자봉적보류시간、일급질보화이급질보작위정성의거；일급질보준분자리자봉면적작위정량의거。결과건립안신류중성약、보건식품중비법첨가14충최면류약물적정성화정량검험측정방법，14충성분선성상관계수（ r）균＞0.99，회수솔80％~120％。결론 RRLC-Q-TOF-NS법정성준학，간우소，정량선성급회수솔량호，괄용우안신류중성약、보건식품비법첨가최면류약품적정성화정량검험。
Objective To establish a qualitative and quantitative analysis method of illegally added 14 hypnotic drugs in Chinese traditional patent medicine and healthy foods. Methods RRLC-Q-TOF-NS was as the detection method. The qualitative analysis was based on the retention time,ms spectrometer and ms/ms spectrometer. The quantitative analysis was based on the quasi-molecular ion peak areas of 14 hypnotic drugs. Results The related coefficients of 14 components were all above 0. 99,the recover factors were between 80% ~120%. The qualitative and quantitative analysis method of illegally added 14 hypnotic drugs in Chinese traditional patent medicine and healthy foods was established. Conclusion This method is accu-rate and less interference,the liner relationships and the recover factors of the quantitative results are all well,which is suitable for the analysis of illegally added 14 hypnotic drugs in Chinese traditional patent medicine and healthy foods.