CAJ | 학술논문

目的：探讨血管内皮生长因子（ VEGF）及其受体FLT-1在直肠癌组织中的表达及其临床病理意义。方法采用免疫组织化学法分别检测82例直肠癌组织中VEGF及其受体FLT-1蛋白的表达，并分析其相关性及临床意义。结果 VEGF在直肠癌组织中阳性表达率为71.9％（59/82），FLT-1在直肠癌组织中的阳性表达率为81.7％（67/82）。VEGF表达与直肠癌淋巴结转移和Duke's分期有关有关（ P＜0.05）。FLT-1表达与浸润深度和淋巴结转移有关（P＜0.05）。VEGF及FLT-1蛋白在直肠癌组织中的表达呈正相关（P＜0.05）。结论 VEGF及其受体FLT-1的表达与直肠癌的侵袭和转移有密切关系，值得进一步研究。
목적：탐토혈관내피생장인자（ VEGF）급기수체FLT-1재직장암조직중적표체급기림상병리의의。방법채용면역조직화학법분별검측82례직장암조직중VEGF급기수체FLT-1단백적표체，병분석기상관성급림상의의。결과 VEGF재직장암조직중양성표체솔위71.9％（59/82），FLT-1재직장암조직중적양성표체솔위81.7％（67/82）。VEGF표체여직장암림파결전이화Duke's분기유관유관（ P＜0.05）。FLT-1표체여침윤심도화림파결전이유관（P＜0.05）。VEGF급FLT-1단백재직장암조직중적표체정정상관（P＜0.05）。결론 VEGF급기수체FLT-1적표체여직장암적침습화전이유밀절관계，치득진일보연구。
Objective To investigate the expression of VEGF and FLT-1 proteins in colorectal carcinoma and analyze their clinicopathological significance. Methods The expression of VEGF and FLT-1 proteins was detected by immunohisto-chemistry in 82 colorectal carcinoma specimens,and the correlation and clinical significance of which were analyzed. Results The positive rates of VEGF protein expression in colorectal carcinoma were 71. 9%(59/82),and the positive rates of FLT-1 were 81. 7%(67/82). The expression of VEGF proteins was found to be associated with lymph node metastasis and Dukes stage in colorectal carcinoma(P<0. 05),and the expression of FLT-1 was associated with depth of infiltration and lymphnode metastasis(P<0. 05). A positive correlation was noted between the expression of VEGF and FLT-1 in colorectal carcinoma (r=0. 565,P<0. 05). Conclusion The expression of VEGF and its receptor FLT-1 is closely associated with the invasion and metastasis of colorectal cancer ,which is worthy of further study.