CAJ | 학술논문

目的：探讨免疫球蛋白A（IgA）在成人癫痫发病机制中的作用。方法选择新诊断成人癫痫患者112例，其中非症状性癫痫（ A组）及症状性癫痫（ B组）各56例，另选体检健康者56例作为对照组。采用胶乳增强免疫比浊法检测3组血清IgA、IgG、IgM、C3、C4水平。结果 A组血清IgA水平明显低于B组及对照组（ P均＜0．05）；3组血清IgG、IgM、C3、C4水平两两比较均无统计学差异（P均＞0．05）。结论 IgA降低可能为成人非症状性癫痫的血生化标志之一，其可能参与了成人癫痫的发病机制。
목적：탐토면역구단백A（IgA）재성인전간발병궤제중적작용。방법선택신진단성인전간환자112례，기중비증상성전간（ A조）급증상성전간（ B조）각56례，령선체검건강자56례작위대조조。채용효유증강면역비탁법검측3조혈청IgA、IgG、IgM、C3、C4수평。결과 A조혈청IgA수평명현저우B조급대조조（ P균＜0．05）；3조혈청IgG、IgM、C3、C4수평량량비교균무통계학차이（P균＞0．05）。결론 IgA강저가능위성인비증상성전간적혈생화표지지일，기가능삼여료성인전간적발병궤제。
Objective To explore the role of immunoglobulin A (IgA) in pathogenesis of adult patients with epilepsy . Methods A total of 112 newly diagnosed adult patients with epilepsy were included .The patients were divided into non-symptomatic epilepsy group (group A, 56 cases) and symptomatic epilepsy group (group B, 56 cases), and another 56 a-dult health volunteer were served as the control group .The serum levels of IgA , IgG, IgM, C3 and C4 were determined by latex enhanced immunoturbidimetry in three groups .Results The serum level of IgA in the group A was significantly lower as compared with those in the group B and control group (all P<0.05).There was no significant difference in the serum levels of IgG, IgM, C3 and C4 between three groups (all P>0.05).Conclusion It is concluded that the decrease of IgA may be one of the biomarkers in the diagnosis of adult non-symptomatic epilepsy , which probably takes part in the patho-genesis of adult epilepsy .