CAJ | 학술논문

目的：通过动物实验应用over-the-scope clip（OTSC）系统闭合经食管行纵隔探查的瘘口，评价其可行性和安全性。方法以狗为实验动物，开展经食管纵隔探查术。共进行10例实验，记录手术时间、术中并发症、术中出血量、手术完成情况、术后实验动物的存活率、体重下降情况以及术后3周食管切口闭合情况。结果10例经食管 NOTES 纵隔探查，平均手术时间24（18～33） min，术中无动物死亡，无胸腔脏器损伤等严重并发症发生。3周后10只实验动物均存活良好，复查胃镜发现OTSC金属夹在位，镜下食管黏膜愈合良好，无脓肿、渗出。结论 OTSC闭合经食管纵隔探查瘘口安全可靠。
목적：통과동물실험응용over-the-scope clip（OTSC）계통폐합경식관행종격탐사적루구，평개기가행성화안전성。방법이구위실험동물，개전경식관종격탐사술。공진행10례실험，기록수술시간、술중병발증、술중출혈량、수술완성정황、술후실험동물적존활솔、체중하강정황이급술후3주식관절구폐합정황。결과10례경식관 NOTES 종격탐사，평균수술시간24（18～33） min，술중무동물사망，무흉강장기손상등엄중병발증발생。3주후10지실험동물균존활량호，복사위경발현OTSC금속협재위，경하식관점막유합량호，무농종、삼출。결론 OTSC폐합경식관종격탐사루구안전가고。
Objective To evaluate the feasibility and safety of endoscopic closure of esophageal perforation with an over-the-scope clip ( OTSC ) system in a surviving canine model.Methods Esophageal perforations (20-mm diameter) were created by an endoscopic needle-knife in 10 dogs.Then the perforations were closed by the OTSC system.And gastroscopy was performed weekly to evaluate the postoperative perforation healing.Results Esophageal perforations could primarily be closed with one OTSC in each experimental dog.The mean handling time was 24 ( 18 -33 ) min.All animals survived without postoperative complications.The retention of OTSC was observed in all dogs at the end of 3 weeks.Conclusion The OTSC system can reliably close esophageal perforations without complications.