CAJ | 학술논문

目的：探讨一氧化氮（NO）以及一氧化氮合酶（NOS）对于再生障碍性贫血（AA）以及缺铁血性贫血（IDA）诊断及疗效判定的意义。方法收集2010年1月-2013年9月期间，该院收治的AA患者24例作为AA组，并收集同期初诊IDA患者24例作为IDA组，选择同期健康体检者24例作为对照组，测定并对比分析3组的血清NO以及NOS水平。结果 AA组以及IDA组的血清NO浓度以及NOS活性均显著高于对照组(P<0.05)，AA组和IDA组之间差异无统计学意义（P>0.05）；经相应治疗后，AA组和IDA组的NO及NOS均恢复正常，且与对照组比较，差异无统计学意义（P>0.05）。结论 NO以及NOS可能参与了AA及IDA的发病过程，对于AA及IDA的诊断以及疗效判定均具有一定的意义。
목적：탐토일양화담（NO）이급일양화담합매（NOS）대우재생장애성빈혈（AA）이급결철혈성빈혈（IDA）진단급료효판정적의의。방법수집2010년1월-2013년9월기간，해원수치적AA환자24례작위AA조，병수집동기초진IDA환자24례작위IDA조，선택동기건강체검자24례작위대조조，측정병대비분석3조적혈청NO이급NOS수평。결과 AA조이급IDA조적혈청NO농도이급NOS활성균현저고우대조조(P<0.05)，AA조화IDA조지간차이무통계학의의（P>0.05）；경상응치료후，AA조화IDA조적NO급NOS균회복정상，차여대조조비교，차이무통계학의의（P>0.05）。결론 NO이급NOS가능삼여료AA급IDA적발병과정，대우AA급IDA적진단이급료효판정균구유일정적의의。
Objective To investigate the significance of nitric oxide (NO) and nitric oxide synthase (NOS) for the diagnosis and cu-rative effect evaluation of aplastic anemia (AA) and iron deficiency anemia (IDA). Methods 24 cases of AA patients admitted in our hospital from January, 2010 to September, 2013 were selected as the AA group, and 24 cases of patients newly diagnosed with IDA patients during the same period were selected as the IDA group, and 24 cases of healthy people underwent physical examina-tion during the same period were selected as the control group. The serum NO and NOS levels of these three groups were mea-sured, compared and analyzed. Results The serum NO concentration and NOS activity in AA group and IDA group were signifi-cantly higher than those of the control group (P<0.05), but there was no significant difference in serum NO concentration and NOS activity between AA group and IDA group (P>0.05); after treatment, the serum NO concentration and NOS activity in AA group and IDA group returned to normal, and compared with those of the control group, the difference was not statistically significant ( P>0.05). Conclusion NO and NOS may be involved in the pathogenesis of AA and IDA, and which have certain significance in the diagnosis and curative effect judgment of AA and IDA.