CAJ | 학술논문

目的：探讨维生素D对毛细支气管炎患儿瘦素、T细胞亚群的影响及意义。方法检测64例毛细支气管炎患儿血清维生素D、瘦素、T细胞亚群，其中30例维生素D检测结果偏低患儿，给予维生素D治疗，30 d复查，与对照组比较。结果64例毛细支气管炎患儿维生素D、CD3(%)、CD8(%)水平显著低于对照组（P<0.05）,而瘦素、CD4（%）、CD4/CD8显著高于对照组（P<0.05）；治疗30 d 时患儿维生素 D、CD3(%)、CD8(%)显著升高（P<0.05），瘦素、CD4/CD8显著下降（P<0.05），CD4虽有下降，但与治疗前差异无统计学意义（P>0.05）。结论维生素D和瘦素参与了毛细支气管炎患儿免疫调节，对于毛细支气管炎患儿适量补充维生素D，能够改善患儿免疫状态。
목적：탐토유생소D대모세지기관염환인수소、T세포아군적영향급의의。방법검측64례모세지기관염환인혈청유생소D、수소、T세포아군，기중30례유생소D검측결과편저환인，급여유생소D치료，30 d복사，여대조조비교。결과64례모세지기관염환인유생소D、CD3(%)、CD8(%)수평현저저우대조조（P<0.05）,이수소、CD4（%）、CD4/CD8현저고우대조조（P<0.05）；치료30 d 시환인유생소 D、CD3(%)、CD8(%)현저승고（P<0.05），수소、CD4/CD8현저하강（P<0.05），CD4수유하강，단여치료전차이무통계학의의（P>0.05）。결론유생소D화수소삼여료모세지기관염환인면역조절，대우모세지기관염환인괄량보충유생소D，능구개선환인면역상태。
Objective To investigate the effects and significance of oral vitamin D on serum leptin and T lymphocyte subpoputation in children with bronchiolitis. Methods The serum vitamin D level, leptin level and T lymphocyte subpoputation of 64 cases of in-fants with bronchiolitis were detected. Of whom, 30 cases who had lower vitamin D level were given the treatment of vitamin D. 30 days after the treatment, the vitamin D level, leptin level and T lymphocyte subpoputation of the patients were redetected, and the detection results were compared with those of the control group. Results The level of vitamin D, CD3 (%), CD8 (%) of 64 infants with bronchiolitis was significantly lower than that of the control group ( P<0.05), but significantly higher in leptin, CD4 (%), CD4/CD8(P<0.05). After 30 days of treatment, the level of vitamin D, CD3(%), CD8(%) significantly elevated (P<0.05) and the level of leptin, CD4/CD8 significantly decreased, compared with the beginning of the treatment ( P<0.05); although the level of CD4 de-creased, compared with that before the treatment, the difference was not statistically significant ( P>0.05). Conclusion Vitamin D and leptin take part in the immune regulation mechanism of bronchiolitis. For children with bronchiolitis, intaking moderate vita-min D can improve the immune state of these children.