辽宁医学院学报
遼寧醫學院學報
료녕의학원학보
JOURNAL OF LIAONING MEDICAL UNIVERSITY
2014年
2期
20-22,23
,共4页
慢性阻塞性肺疾病%喜炎平注射液%左氧氟沙星
慢性阻塞性肺疾病%喜炎平註射液%左氧氟沙星
만성조새성폐질병%희염평주사액%좌양불사성
chronic obstructive pulmonary disease%Xiyanping injection%levofloxacin
目的：观察喜炎平注射液联合左氧氟沙星治疗慢性阻塞性肺疾病伴感染的临床疗效。方法将82例患者随机分为两组，均予控制性氧疗、抗生素、糖皮质激素、支气管扩张剂、祛痰剂等，同时纠正水电解质紊乱及酸碱平衡失调等。治疗组（喜炎平注射液联合左氧氟沙星治疗组）及对照组（左氧氟沙星组），各组均治疗10 d；比较各组临床疗效及细菌清除率。结果对照组：痊愈16例，显效6例，进步15例，无效3例，有效率55％；治疗组：痊愈20例，显效14例，进步3例，无效5例，有效率80.9％；治疗组与对照组有效率差异具有统计学意义（χ2＝8.571， P＝0.003）。82例患者培养出致病菌52例（每组各26例），经过治疗，两组肺炎克雷伯杆菌、流感嗜血杆菌、绿脓杆菌、金黄色葡萄球菌、大肠杆菌及肺炎链球菌清除率比较，差异有统计学意义（ P＜0.01），治疗组总清除率为69.2％，对照组为38.5％；表皮葡萄球菌、卡他球菌清除率差异均无统计学意义（ P＞0.05）。结论喜炎平联合左氧氟沙星治疗慢性阻塞性肺疾病伴感染疗效满意，无明显不良反应。
目的：觀察喜炎平註射液聯閤左氧氟沙星治療慢性阻塞性肺疾病伴感染的臨床療效。方法將82例患者隨機分為兩組，均予控製性氧療、抗生素、糖皮質激素、支氣管擴張劑、祛痰劑等，同時糾正水電解質紊亂及痠堿平衡失調等。治療組（喜炎平註射液聯閤左氧氟沙星治療組）及對照組（左氧氟沙星組），各組均治療10 d；比較各組臨床療效及細菌清除率。結果對照組：痊愈16例，顯效6例，進步15例，無效3例，有效率55％；治療組：痊愈20例，顯效14例，進步3例，無效5例，有效率80.9％；治療組與對照組有效率差異具有統計學意義（χ2＝8.571， P＝0.003）。82例患者培養齣緻病菌52例（每組各26例），經過治療，兩組肺炎剋雷伯桿菌、流感嗜血桿菌、綠膿桿菌、金黃色葡萄毬菌、大腸桿菌及肺炎鏈毬菌清除率比較，差異有統計學意義（ P＜0.01），治療組總清除率為69.2％，對照組為38.5％；錶皮葡萄毬菌、卡他毬菌清除率差異均無統計學意義（ P＞0.05）。結論喜炎平聯閤左氧氟沙星治療慢性阻塞性肺疾病伴感染療效滿意，無明顯不良反應。
목적：관찰희염평주사액연합좌양불사성치료만성조새성폐질병반감염적림상료효。방법장82례환자수궤분위량조，균여공제성양료、항생소、당피질격소、지기관확장제、거담제등，동시규정수전해질문란급산감평형실조등。치료조（희염평주사액연합좌양불사성치료조）급대조조（좌양불사성조），각조균치료10 d；비교각조림상료효급세균청제솔。결과대조조：전유16례，현효6례，진보15례，무효3례，유효솔55％；치료조：전유20례，현효14례，진보3례，무효5례，유효솔80.9％；치료조여대조조유효솔차이구유통계학의의（χ2＝8.571， P＝0.003）。82례환자배양출치병균52례（매조각26례），경과치료，량조폐염극뢰백간균、류감기혈간균、록농간균、금황색포도구균、대장간균급폐염련구균청제솔비교，차이유통계학의의（ P＜0.01），치료조총청제솔위69.2％，대조조위38.5％；표피포도구균、잡타구균청제솔차이균무통계학의의（ P＞0.05）。결론희염평연합좌양불사성치료만성조새성폐질병반감염료효만의，무명현불량반응。
Object ive To observe the clinical effects of Xiyanping injection in combination with levofloxacin to cure chronic ob-structive pulmonary diseases with infection.Methods 82 patients were randomly divided into two groups.All patients were treated with controlled oxygen therapy, antibiotics, corticosteroids, bronchodilators, expectorants, while at same timecorrecting water electro-lyte imbalance and acid-base imbalance etc.The treatment group ( n=41 ) was cured with Xiyanping injection in combination with levofloxacin .The control group ( n=41 ) was cured with levofloxacin .The control group and treatment group were all treated for 10 days, and the clinical effect and bacterial clearance were compared.Results In the control group, 16 cases recovered, 6 cases were effective, 15 cases progressed, 3 cases were invalid, and the effective rate was 55.0%.In the treatment group, 20 cases recovered, 14 cases were effective, 3 cases progressed, 5 cases were invalid, and the effective rate is 80.9%, there was statistically significant difference in the effective rate (χ2=8.571, P=0.003) between the treatment group and the control group.Of 82 patients, cultured pathogens were cultured in 52 cases (26 cases in each group).After treatment, there was between the two groups statistically signifi-cant difference ( P<0.01 ) in the bacterial clearance of Klebsiella pneumoniae , haemophilus influenzae ,Pseudomonas aeruginosa , Staphylococcus aureus, escherichia coli and streptococcus pneumoniae .The total bacterial clearance of the treatment group was 69.2% and the total bacterial clearance of the control group was 38.5%.There was no statistical significance in the bacterial clearance of staphylococcus epidermidis and catarrhal coccus of the two groups ( P>0.05 ) .Conclusion The effect of Xiyanping injection in combination with levofloxacin in the treatment of chronic obstructive pulmonary disease with infection was satisfactory , and there was no significant adverse reaction.
