CAJ | 학술논문

　　超临界抗溶剂造粒技术由于具有操作条件温和、制得的微粒有机溶剂残留少、微粒粒径和形态可控等优点，已广泛地应用于药物运输体系的研究当中。本文简要介绍了超临界抗溶剂造粒技术的基本原理、装置组成和基本分类；从技术发展、喷嘴改进、技术结合、产品收集等方面，详细阐述了GAS、ASES、SEDS、SEDS-PA、SpEDS、SAS-EM、SAS-IJ、连续式 RESS 以及 RESAS 等基于超临界流体抗溶剂原理的造粒技术及其装置的改进过程；然后对目前其中存在的颗粒团聚、产品收集难和装置资源没有充分利用等问题提出了可能的解决方案；最后从数学模型的建立和规模化两方面，对超临界抗溶剂造粒技术基础理论的完善及其装置的改进进行了展望。
　　초림계항용제조립기술유우구유조작조건온화、제득적미립유궤용제잔류소、미립립경화형태가공등우점，이엄범지응용우약물운수체계적연구당중。본문간요개소료초림계항용제조립기술적기본원리、장치조성화기본분류；종기술발전、분취개진、기술결합、산품수집등방면，상세천술료GAS、ASES、SEDS、SEDS-PA、SpEDS、SAS-EM、SAS-IJ、련속식 RESS 이급 RESAS 등기우초림계류체항용제원리적조립기술급기장치적개진과정；연후대목전기중존재적과립단취、산품수집난화장치자원몰유충분이용등문제제출료가능적해결방안；최후종수학모형적건립화규모화량방면，대초림계항용제조립기술기출이론적완선급기장치적개진진행료전망。
With the great advantages,such as mild operating condition,less or no residual organic solvent and controllable particle size distribution and morphology of products,supercritical antisolvent (SAS) process for particle formation has been widely employed in drug delivery systems (DDS). The fundamental theory,compositions of apparatus and classification for particle formation technology based on SAS process were briefly introduced in this paper. Then the developments of particle formation technology and its apparatus based on SAS process,including the GAS,ASES,SEDS, SEDS-PA,SpEDS,SAS-EM,SAS-IJ,continuous RESS and RESAS processes,were summarized and addressed in more detail with respect to developments of technologies,improvements of nozzle, combinations of technologies and collections of products. The possible solutions for the existing problems such as the agglomeration of particles,difficulty in products collections,and failure in making full use of apparatus,were proposed. Finally,the prospect of development about basic theory in particle formation technology and improvements in apparatus based on SAS process were also presented from two aspects:development of mathematical model and scale-up of SAS process.