CAJ | 학술논문

甘肃为我国胃癌高发区,胃癌病死率居全国之首,安全有效的治疗是研究重点.近年来,随着对肿瘤分子生物学机制研究的不断深入,肿瘤的靶向治疗已成为研究的新方向.大量研究结果表明:环氧合酶(COX)的过度表达在肿瘤的发生、发展中起着重要作用,非甾体类抗炎药塞来昔布是一种新型COX-2选择性抑制剂,可明显降低消化道肿瘤的发病率.它通过抑制肿瘤生长和肿瘤新生血管生成,诱导肿瘤细胞凋亡,逆转多药耐药,增强化疗药的细胞毒作用和放射敏感性,与化、放疗产生协同作用,从而抑制肿瘤的发生、发展.因此,以COX-2为特异靶点的治疗策略有望为胃癌治疗提供新的思路,具有良好的临床应用前景.
감숙위아국위암고발구,위암병사솔거전국지수,안전유효적치료시연구중점.근년래,수착대종류분자생물학궤제연구적불단심입,종류적파향치료이성위연구적신방향.대량연구결과표명:배양합매(COX)적과도표체재종류적발생、발전중기착중요작용,비치체류항염약새래석포시일충신형COX-2선택성억제제,가명현강저소화도종류적발병솔.타통과억제종류생장화종류신생혈관생성,유도종류세포조망,역전다약내약,증강화료약적세포독작용화방사민감성,여화、방료산생협동작용,종이억제종류적발생、발전.인차,이COX-2위특이파점적치료책략유망위위암치료제공신적사로,구유량호적림상응용전경.
Gansu province is a high incidence area of gastric cancer,and the mortality caused by gastric cancer ranks first in China.A safe and effective treatment of gastric cancer is the key point in the research.In recent years,tumor-targeted therapy has become a new research direction along with the gradually increased understanding of the molecular biology of cancer mechanism.Several studies have shown that increased expression of cyclooxygenase (COX)-2 plays an important role in the occurrence and development of malignant tumor.Celecoxib,a non-steroidal anti-inflammatory drug,is a novel COX-2 selective inhibitor which can significantly reduce the incidence of gastrointestinal malignancy,and inhibit tumorigenesis through inhibiting tumor growth and tumor angiogenesis,inducing the apoptosis of tumor cells,reversing multidrug resistance,enhancing the cytotoxicity and radiosensitivity of chemotherapy drugs,and producing synergistic effects with combining chemotherapy and radiotherapy.Therefore,celecoxib has the potential to be the treatment of choice for gastric cancer.