国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
23期
3555-3558
,共4页
高敏C反应蛋白%脑钠肽%肌钙蛋白Ⅰ%急性冠状动脉综合征
高敏C反應蛋白%腦鈉肽%肌鈣蛋白Ⅰ%急性冠狀動脈綜閤徵
고민C반응단백%뇌납태%기개단백Ⅰ%급성관상동맥종합정
Hs-CRP%Brain natriuretic peptide%Cardiac troponin Ⅰ%Acute coronary syndrome
目的 探讨高敏C反应蛋白(hs-CRP)、脑钠肽(BNP)和心肌肌钙蛋白Ⅰ(cTNⅠ)在急性冠状动脉综合征(ACS)患者血清中的表达水平及其检测的临床意义.方法 我科收治的ACS患者43例(ACS组)和健康查体者46例(对照组)作为研究对象.酶联免疫吸附法检测上述患者血清CRP、BNP和cTNⅠ水平,比较两组患者血清hs-CRP、BNP及cTNⅠ水平有无差异及其在ACS组患者中的相关性.结果 ACS组血浆hs-CRP、BNP和cTNⅠ分别为(6.88±2.11) mg/L,(311.6±88.9) pg/ml和(17.4±9.1) pg/ml;对照组分另别为(2.67±1.12) mg/L,(21.8±8.9) pg/ml和(0.14±0.10) pg/ml,ACS组上述指标均显著高于对照组,差异有统计学意义(P＜0.05);ACS组患者血浆hs-CRP、BNP与cTNⅠ之间存在正相关,pearson相关系数r分别为0.81(P＜ 0.05)和0.47(P＜0.05).结论 ACS患者血清hs-CRP、BNP和cTNⅠ显著升高,且三者间存在相关性,可作为临床诊断ACS的血清学标志物.
目的 探討高敏C反應蛋白(hs-CRP)、腦鈉肽(BNP)和心肌肌鈣蛋白Ⅰ(cTNⅠ)在急性冠狀動脈綜閤徵(ACS)患者血清中的錶達水平及其檢測的臨床意義.方法 我科收治的ACS患者43例(ACS組)和健康查體者46例(對照組)作為研究對象.酶聯免疫吸附法檢測上述患者血清CRP、BNP和cTNⅠ水平,比較兩組患者血清hs-CRP、BNP及cTNⅠ水平有無差異及其在ACS組患者中的相關性.結果 ACS組血漿hs-CRP、BNP和cTNⅠ分彆為(6.88±2.11) mg/L,(311.6±88.9) pg/ml和(17.4±9.1) pg/ml;對照組分另彆為(2.67±1.12) mg/L,(21.8±8.9) pg/ml和(0.14±0.10) pg/ml,ACS組上述指標均顯著高于對照組,差異有統計學意義(P＜0.05);ACS組患者血漿hs-CRP、BNP與cTNⅠ之間存在正相關,pearson相關繫數r分彆為0.81(P＜ 0.05)和0.47(P＜0.05).結論 ACS患者血清hs-CRP、BNP和cTNⅠ顯著升高,且三者間存在相關性,可作為臨床診斷ACS的血清學標誌物.
목적 탐토고민C반응단백(hs-CRP)、뇌납태(BNP)화심기기개단백Ⅰ(cTNⅠ)재급성관상동맥종합정(ACS)환자혈청중적표체수평급기검측적림상의의.방법 아과수치적ACS환자43례(ACS조)화건강사체자46례(대조조)작위연구대상.매련면역흡부법검측상술환자혈청CRP、BNP화cTNⅠ수평,비교량조환자혈청hs-CRP、BNP급cTNⅠ수평유무차이급기재ACS조환자중적상관성.결과 ACS조혈장hs-CRP、BNP화cTNⅠ분별위(6.88±2.11) mg/L,(311.6±88.9) pg/ml화(17.4±9.1) pg/ml;대조조분령별위(2.67±1.12) mg/L,(21.8±8.9) pg/ml화(0.14±0.10) pg/ml,ACS조상술지표균현저고우대조조,차이유통계학의의(P＜0.05);ACS조환자혈장hs-CRP、BNP여cTNⅠ지간존재정상관,pearson상관계수r분별위0.81(P＜ 0.05)화0.47(P＜0.05).결론 ACS환자혈청hs-CRP、BNP화cTNⅠ현저승고,차삼자간존재상관성,가작위림상진단ACS적혈청학표지물.
Objective To evaluate the clinical significance of serum hs-CRP,BNP and cTNⅠ in patients with acute coronary syndrome.Methods 43 cases of ACS and 46 health examinees in our hospital were recruited as study object.The serum levels of hs-CRP,BNP and cTNⅠ were tested by ELISA and compared between two groups.Results The serum levels of hs-CRP,BNP and cTNI in ACS group were (6.88 ± 2.11) mg/L,(311.6 ± 88.9) pg/ml and (17.4 ± 9.1) pg/ml respectively,those in control group were (2.67 ± 1.12) mg/L,(21.8 ± 8.9) pg/ml,(0.14 ± 0.10) pg/ml respectively.The serum levels of hs-CRP,BNP and cTNⅠ in ACS group were significantly higher than those in control group (P ＜ 0.05).The serum level of cTNⅠin patients with ACS was related to the serum levels of hs-CRP and BNP,with Pearson correlation coefficients of 0.81 and 0.47 (P ＜ 0.05).Conclusions The serum levels of hs-CRP,BNP and cTNⅠ in patients with ACS are significantly increased,which can be used as serum biomarker for the diagnosis of ACS.
