CAJ | 학술논문

目的：研究垂体瘤转化基因（ pituitary tumor-transforming gene， PTTG）在淋巴瘤患者中的表达，探讨其与淋巴瘤发生的关系及临床意义。方法采用RT-PCR方法检测32例非霍奇金淋巴瘤（ non-Hodgkin's Lymphoma， NHL）及10例慢性淋巴结炎患者骨髓单个核细胞（bone marrow mononuclear cell， BMMNC）中PTTG 基因的表达。结果32例NHL患者有18例（56.3％）存在PTTG基因的表达，其中外周T细胞淋巴瘤有55.6％（5/9例）、弥漫大B细胞淋巴瘤有56.5％（13/23例）。 NHL患者PTTG基因的表达水平明显高于慢性淋巴结炎患者（P＜0.05），外周T细胞淋巴瘤和弥漫大B细胞淋巴瘤患者PTTG基因的表达水平差异无统计学意义（ P＞0.05）。结论 PTTG基因的过度表达可能和淋巴瘤的发生发展有关。
목적：연구수체류전화기인（ pituitary tumor-transforming gene， PTTG）재림파류환자중적표체，탐토기여림파류발생적관계급림상의의。방법채용RT-PCR방법검측32례비곽기금림파류（ non-Hodgkin's Lymphoma， NHL）급10례만성림파결염환자골수단개핵세포（bone marrow mononuclear cell， BMMNC）중PTTG 기인적표체。결과32례NHL환자유18례（56.3％）존재PTTG기인적표체，기중외주T세포림파류유55.6％（5/9례）、미만대B세포림파류유56.5％（13/23례）。 NHL환자PTTG기인적표체수평명현고우만성림파결염환자（P＜0.05），외주T세포림파류화미만대B세포림파류환자PTTG기인적표체수평차이무통계학의의（ P＞0.05）。결론 PTTG기인적과도표체가능화림파류적발생발전유관。
Objective To explore the expression of PTTG in patients with non-Hodgkin's lymphoma ( NHL), its relationship with NHL and its clinical significance.Method PTTG gene expression on bone marrow mononuclear cell (BMMNC) in 32 patients with non-hodgkin Lymphoma (NHL) and 10 patients with chronic lymphadenitis were detected by RT-PCR method. Results 18 of 32 (56.3%) cases with NHL were observed with PTTG gene expression, among which there were peripheral T cell lymphoma 55.6%(5/9 cases), 56.5% (13/23 cases) of diffuse large B cell lymphoma.PTTG gene expression levels of patients with NHL were significantly higher than those in patients with chronic lymphadenitis ( P<0.05 ) .PTTG gene expression difference in patients with peripheral T cell lymphoma and in patients with diffuse large B cell lymphoma is of no statistical significance ( P>0.05 ) .Conclu-sion The overexpression of PTTG gene may be related to the occurrence and development of lymphoma .