CAJ | 학술논문

目的：观察广西地区慢性肾炎中医证型的分布规律，并探讨其与尿蛋白、肾功能等实验室指标的相关性。方法对140例慢性肾炎患者的一般情况、分期、中医主证和标证型进行统计描述，检测患者的尿蛋白、肾功能（尿素氮（ BUN）、血肌酐（ SCr）），并分析中医证型与这些实验检查指标的关系。结果140例慢性肾炎患者本证中，中医证型分布和 CKD分期有相关性（P＜0.001），Ⅰ期和Ⅱ期与脾肾气虚证相关；Ⅲ期与肝肾阴虚型相关，Ⅳ期与脾肾阳虚证相关。标证中，从Ⅰ期进展至Ⅳ期，外感证、湿浊证和瘀血证均逐渐增多，但湿热证则有减少的趋势。肝肾阴虚证和脾肾气虚证患者的尿蛋白、BUN、SCr水平差异无统计学意义。而与肝肾阴虚证和脾肾气虚证相比较，脾肾阳虚证患者的尿蛋白、BUN、SCr 水平明显升高（P均＜0.01）。结论广西地区慢性肾炎证型演变规律为脾肾气虚-肝肾阴虚-脾肾阳虚，瘀血证和湿浊是最主要的指标。尿蛋白、BUN、SCr水平与脾肾阳虚证可能存在一定相关性，临床上可能作为辨证论治的客观指标。
목적：관찰엄서지구만성신염중의증형적분포규률，병탐토기여뇨단백、신공능등실험실지표적상관성。방법대140례만성신염환자적일반정황、분기、중의주증화표증형진행통계묘술，검측환자적뇨단백、신공능（뇨소담（ BUN）、혈기항（ SCr）），병분석중의증형여저사실험검사지표적관계。결과140례만성신염환자본증중，중의증형분포화 CKD분기유상관성（P＜0.001），Ⅰ기화Ⅱ기여비신기허증상관；Ⅲ기여간신음허형상관，Ⅳ기여비신양허증상관。표증중，종Ⅰ기진전지Ⅳ기，외감증、습탁증화어혈증균축점증다，단습열증칙유감소적추세。간신음허증화비신기허증환자적뇨단백、BUN、SCr수평차이무통계학의의。이여간신음허증화비신기허증상비교，비신양허증환자적뇨단백、BUN、SCr 수평명현승고（P균＜0.01）。결론엄서지구만성신염증형연변규률위비신기허-간신음허-비신양허，어혈증화습탁시최주요적지표。뇨단백、BUN、SCr수평여비신양허증가능존재일정상관성，림상상가능작위변증론치적객관지표。
Objective It is tO Observe the evOlvement rule Of Chinese medical syndrOme typing Of chrOnic nephritis in Guangxi area and its cOrrelatiOn with examinatiOn indexes such as urine prOtein and renal functiOn. Methods Statistical de-scriptiOns Of the nOrmal cOnditiOn,stage,incidental symptOm and fundamental symptOm Of TCM Of 140 patients with chrOnic nephritis were made,and urine prOtein,renal functiOn( BUN,SCr)were determined tO analyze the relatiOnship between TCM syndrOmes and examinatiOn indexes. Results In the fundamental symptOms Of 140 patients with chrOnic nephritis,the syn-drOme types Of TCM were cOrrelated with CKD stage(P <0. 001),stage Ⅰ and Ⅱ were related with spleen-kidney Qi-defi-ciency,stage Ⅲ was related with liver-kidney Yin-deficiency,stage Ⅳ was related with spleen-kidney Yang-deficiency. In in-cidental symptOms,exOgenOus syndrOme,turbid dampness syndrOme and blOOd stasis syndrOme increased gradually,but heat dampness syndrOme had a decreasing tendency. There was nO significant difference in urine prOtein,BUN and SCr levels be-tween spleen-kidney Qi-deficiency and liver-kidney Yin-deficiency patients,but the levels increased ObviOusly in spleen-kid-ney Yang-deficiency patients(P<0. 01). Conclusion The evOlvement rule Of Chinese medical syndrOme typing Of chrOnic ne-phritis in Guangxi area is that spleen-kidney Qi-deficiency-liver-kidney Yin-deficiency-spleen-kidney Yang-deficiency,blOOd stasis syndrOme and damp-turbid are main indexes. The levels Of urine prOtein,BUN and SCr are related with spleen-kidney Yang-deficiency,which can be used as Objective indexes fOr syndrOme differentiatiOn and treatment.