CAJ | 학술논문

目的：探讨氯沙坦与培哚普利联合应用对老年高血压患者左室肥厚及纤维蛋白原的影响。方法：2012年-2013年收治高血压合并左室肥厚老年患者90例，所有患者均采用氯沙坦联合培哚普利治疗，治疗前及治疗后6个月，对患者进行心脏超声检查，测定左心室质量指数(LVMI)，同时进行血浆纤维蛋白原(Fg)检测，观察患者治疗前后两者变化。结果：治疗后与治疗前比较，LVMI及Fg含量均明显降低，差异有统计学意义(P＜0.05)。结论：氯沙坦与培哚普利联合用药治疗老年性高血压，能逆转左心室肥厚，降低Fg含量，值得在临床推广。
목적：탐토록사탄여배타보리연합응용대노년고혈압환자좌실비후급섬유단백원적영향。방법：2012년-2013년수치고혈압합병좌실비후노년환자90례，소유환자균채용록사탄연합배타보리치료，치료전급치료후6개월，대환자진행심장초성검사，측정좌심실질량지수(LVMI)，동시진행혈장섬유단백원(Fg)검측，관찰환자치료전후량자변화。결과：치료후여치료전비교，LVMI급Fg함량균명현강저，차이유통계학의의(P＜0.05)。결론：록사탄여배타보리연합용약치료노년성고혈압，능역전좌심실비후，강저Fg함량，치득재림상추엄。
Objective:To explore the influence of losartan combined with perindopril on older hypertensive left ventricular hypertrophy and plasma fibrinogen.Methods:90 elderly cases with essential hypertension and left ventricular hypertrophy were selected from 2012 to 2013.All cases were treated with losartan and perindopril treatment.Before treatment and at 6 months after the treatment,they received cardiac ultrasound examination to determinate the left ventricular mass index(LVMI).At the same time, they received the plasma fibrinogen(Fg) detection.We observed the changes of left ventricular mass index and the content of fibrinogen of all patients before and after treatment.Results:Compared before and after treatment,LVMI and Fg content were decreased.The difference was statistically significant(P<0.05).Conclusion:The application of losartan combined with perindopril in the treatment of hypertension in the elderly,can reverse left ventricular hypertrophy,and decrease the content of Fg.It is worthy of clinical application.