皮肤病与性病
皮膚病與性病
피부병여성병
JOURNAL OF DERMATOLOGY AND VENEROLOGY
2014年
3期
125-128,133
,共5页
黄晓凤%王银娟%郭美华%何黎%杜雅萍%张书良
黃曉鳳%王銀娟%郭美華%何黎%杜雅萍%張書良
황효봉%왕은연%곽미화%하려%두아평%장서량
黄褐斑%旁氏无暇透白日霜%皮肤屏障%TEWL%角质层含水量%LAB值
黃褐斑%徬氏無暇透白日霜%皮膚屏障%TEWL%角質層含水量%LAB值
황갈반%방씨무가투백일상%피부병장%TEWL%각질층함수량%LAB치
Melasma%Skin whitening%POND'S ultra luminous day cream (SPF15/ PA++)%Skin barrier%TEWL%Water content in stratum corneum%LAB
目的：观察旁氏无暇透白日霜( SPF 15 PA++)改善黄褐斑临床症状及皮肤屏障功能的疗效。方法采用随机双盲、自身对照的临床研究方法。选取30例面部皮损较对称的黄褐斑患者,受试者每天用温水清洁面部,半脸使用约0.5g测试产品,另外半脸使用等量对照产品,早晚各1次,2次/d。分别于首诊、治疗后第28天、56天评估皮损情况。结果①主观比较：实验组基本治愈0例,显效4例,好转10例,无效16例,总有效率46.6%。对照组基本治愈0例,显效1例,好转5例,无效24例,总有效率20.0%。治疗组与对照组疗效经卡方检验差异有统计学意义( P<0.05)。② TEWL值：试验组与对照组随时间延长TEWL值均值均有所降低,治疗组与对照组相比0、28、56天P值均>0.05,差异无统计学意义。③皮肤角质层含水量：试验组与对照组随时间延长皮肤角质层含水量均值均有所升高,治疗组与对照组相比0、28天P值均>0.05,差异无统计学意义,第56天时,试验组角质层含水量(41.14±5.94)与对照组角质层含水量(41.90±5.81)比较,差异有统计学意义(P<0.05)。④ LAB值检测：随时间延长实验组与对照组LabL值均值均有所升高、LabA值均值无明显变化、LabB值均值均有所下降。实验组与对照组相比,LabL值0、28天P值均>0.05,差异无统计学意义；56天时,实验组LabL值(58.92±3.52)与对照组LabL值(56.86±3.11)相比,差异有统计学意义(P<0.05)。 LabA值0、28、56天 P值均>0.05,差异无统计学意义。 LabB值0、28天 P值均>0.05,差异无统计学意义；56天时,实验组LabB值(15.21±1.90)与对照组LabB值(16.16±1.52)相比,差异有统计学意义(P<0.05)。结论受试品“旁氏无暇透白日霜”和对照品市售“凡士林保湿露”均具有良好的美白、保湿、恢复皮肤屏障的效果,并且“旁氏无暇透白日霜”美白效果显著优于对照品市售“凡士林保湿露”。
目的：觀察徬氏無暇透白日霜( SPF 15 PA++)改善黃褐斑臨床癥狀及皮膚屏障功能的療效。方法採用隨機雙盲、自身對照的臨床研究方法。選取30例麵部皮損較對稱的黃褐斑患者,受試者每天用溫水清潔麵部,半臉使用約0.5g測試產品,另外半臉使用等量對照產品,早晚各1次,2次/d。分彆于首診、治療後第28天、56天評估皮損情況。結果①主觀比較：實驗組基本治愈0例,顯效4例,好轉10例,無效16例,總有效率46.6%。對照組基本治愈0例,顯效1例,好轉5例,無效24例,總有效率20.0%。治療組與對照組療效經卡方檢驗差異有統計學意義( P<0.05)。② TEWL值：試驗組與對照組隨時間延長TEWL值均值均有所降低,治療組與對照組相比0、28、56天P值均>0.05,差異無統計學意義。③皮膚角質層含水量：試驗組與對照組隨時間延長皮膚角質層含水量均值均有所升高,治療組與對照組相比0、28天P值均>0.05,差異無統計學意義,第56天時,試驗組角質層含水量(41.14±5.94)與對照組角質層含水量(41.90±5.81)比較,差異有統計學意義(P<0.05)。④ LAB值檢測：隨時間延長實驗組與對照組LabL值均值均有所升高、LabA值均值無明顯變化、LabB值均值均有所下降。實驗組與對照組相比,LabL值0、28天P值均>0.05,差異無統計學意義；56天時,實驗組LabL值(58.92±3.52)與對照組LabL值(56.86±3.11)相比,差異有統計學意義(P<0.05)。 LabA值0、28、56天 P值均>0.05,差異無統計學意義。 LabB值0、28天 P值均>0.05,差異無統計學意義；56天時,實驗組LabB值(15.21±1.90)與對照組LabB值(16.16±1.52)相比,差異有統計學意義(P<0.05)。結論受試品“徬氏無暇透白日霜”和對照品市售“凡士林保濕露”均具有良好的美白、保濕、恢複皮膚屏障的效果,併且“徬氏無暇透白日霜”美白效果顯著優于對照品市售“凡士林保濕露”。
목적：관찰방씨무가투백일상( SPF 15 PA++)개선황갈반림상증상급피부병장공능적료효。방법채용수궤쌍맹、자신대조적림상연구방법。선취30례면부피손교대칭적황갈반환자,수시자매천용온수청길면부,반검사용약0.5g측시산품,령외반검사용등량대조산품,조만각1차,2차/d。분별우수진、치료후제28천、56천평고피손정황。결과①주관비교：실험조기본치유0례,현효4례,호전10례,무효16례,총유효솔46.6%。대조조기본치유0례,현효1례,호전5례,무효24례,총유효솔20.0%。치료조여대조조료효경잡방검험차이유통계학의의( P<0.05)。② TEWL치：시험조여대조조수시간연장TEWL치균치균유소강저,치료조여대조조상비0、28、56천P치균>0.05,차이무통계학의의。③피부각질층함수량：시험조여대조조수시간연장피부각질층함수량균치균유소승고,치료조여대조조상비0、28천P치균>0.05,차이무통계학의의,제56천시,시험조각질층함수량(41.14±5.94)여대조조각질층함수량(41.90±5.81)비교,차이유통계학의의(P<0.05)。④ LAB치검측：수시간연장실험조여대조조LabL치균치균유소승고、LabA치균치무명현변화、LabB치균치균유소하강。실험조여대조조상비,LabL치0、28천P치균>0.05,차이무통계학의의；56천시,실험조LabL치(58.92±3.52)여대조조LabL치(56.86±3.11)상비,차이유통계학의의(P<0.05)。 LabA치0、28、56천 P치균>0.05,차이무통계학의의。 LabB치0、28천 P치균>0.05,차이무통계학의의；56천시,실험조LabB치(15.21±1.90)여대조조LabB치(16.16±1.52)상비,차이유통계학의의(P<0.05)。결론수시품“방씨무가투백일상”화대조품시수“범사림보습로”균구유량호적미백、보습、회복피부병장적효과,병차“방씨무가투백일상”미백효과현저우우대조품시수“범사림보습로”。
Objective To observe the curative effects of POND ' S ultra luminous day cream ( SPF15/ PA++, POND'S in brief) in improving the symptoms and barrier function of patients with melasma. Methods 30 patients of melasma with balanced facial skin lesion were selected in the clinical observation. The patients wash their faces with warm water in the morning and night every day, then topically apply about 0. 5g sample of POND'S on one half of the face and the same quality of control substance, which is Vaseline moisturizing lotion made by Unilever company, on another half of the face simultaneously. The lesions were observed and evaluated at the first, the 28th and the 56th day respectively through randomized double-blind, self-control clinical researching method. Results ① 4 cases had marked effect, 10 cases were improved, 16 had no effect in treatment group, the total effective rate of which was 46. 6%. 1 case had marked effect, 5 cases were improved, 24 cases had no effect in control group, the total effective rate of which was 20%. The difference of the curative effect in two groups was statistically significant ( P<0 . 05 ) .②The TEWL mean values of treatment group and control group are both reduced in time -development manner, but there have no significant difference ( P>0 . 05 ) . ③ The mean values of water content in stratum corneum in both groups are raised in time-development manner, but have no significant difference at the 1st and the 28th day ( P>0. 05). At the 56th day, the water content in stratum corneum of treatment group (41. 14±5. 94) is lower than that of control group (41. 90±5. 81) (P<0. 05). ④ The mean LabL values of both groups are raised, the mean LabA values have no significant change, while the mean LabB values are reduced. The treatment group compared with con-trol group, LabL value at 0, 28 days (P>0. 05), there was no statistically significant difference; the experimental group LabL value (58. 92 + 3. 52) compared with control group LabL value (56. 86-3. 11) at 56 days, the differ-ence was statistically significant ( P< 0 . 05 ) . LabA value at 0 , 28 , 56 days ( P>0 . 05 ) , there was no statistically significant difference. LabB value at 0,28 days (P>0. 05), there was no statistically significant difference; the ex-perimental group LabB value (15. 21+1. 90) compared with control group LabB value (16. 16-1. 52) at 56 days, the difference was statistically significant ( P<0 . 05 ) . Conclusion Both the sample of POND ' S ultra luminous day cream and the control substance of Vaseline moisturizing lotion have shown a good effect of skin whitening, moisturiz-ing and recovering the skin barrier. The POND'S ultra luminous day cream shows a better effect on skin whitening.
