中国实验诊断学
中國實驗診斷學
중국실험진단학
CHINESE JOURNAL OF LABORATORY DIAGNOSIS
2014年
9期
1457-1460
,共4页
急性心肌梗死%MMP-9%IL-6%P 选择素
急性心肌梗死%MMP-9%IL-6%P 選擇素
급성심기경사%MMP-9%IL-6%P 선택소
Acute myocardial infarction%coronary intervention%MMP-9%IL-6%Ps
目的:测定研究对象的血浆 MMP、IL-6和 Ps 水平,分析探讨冠状动脉介入术干预前后急性心肌梗死患者MMP-9、IL-6及 P 选择素变化的临床意义。方法选择本院收治的68例临床接受冠状动脉介入干预的急性心肌梗死患者作为冠脉介入手术组,同时选择同期本院健康体检者66例作为对照组,采用酶联免疫吸附法测定研究对象介入干预前后 MMP-9、IL-6水平和 P 选择素水平。结果急性心肌梗死患者干预前 MMP-9(704.03±122.54)和 P 选择素(192.34±103.51)显著高于对照组的(312.67±82.79)和(121.27±69.13)、IL-6(50.62±11.17)低于对照组的(71.38±15.75)(P <0.05);冠状动脉介入术干预前后,急性心肌梗死患者的各指标发生变化,差异有统计学意义(P<0.05);接受冠状动脉介入术后的急性梗死患者的各指标与对照组研究对象相比无差异(P <0.05)。IL-6水平 P 选择素浓度低于干预前(P <0.05);接受冠脉介入术的急性心肌梗死患者的 MMP-9、IL-6水平 P 选择素比对照组患者相应指标降低更加明显(P <0.05)。结论急性心肌梗死患者接受冠脉介入干预可以降低机体 MMP-9和 P 选择素水平,升高 IL-6水平,改善病人心功能,具有一定的临床意义。
目的:測定研究對象的血漿 MMP、IL-6和 Ps 水平,分析探討冠狀動脈介入術榦預前後急性心肌梗死患者MMP-9、IL-6及 P 選擇素變化的臨床意義。方法選擇本院收治的68例臨床接受冠狀動脈介入榦預的急性心肌梗死患者作為冠脈介入手術組,同時選擇同期本院健康體檢者66例作為對照組,採用酶聯免疫吸附法測定研究對象介入榦預前後 MMP-9、IL-6水平和 P 選擇素水平。結果急性心肌梗死患者榦預前 MMP-9(704.03±122.54)和 P 選擇素(192.34±103.51)顯著高于對照組的(312.67±82.79)和(121.27±69.13)、IL-6(50.62±11.17)低于對照組的(71.38±15.75)(P <0.05);冠狀動脈介入術榦預前後,急性心肌梗死患者的各指標髮生變化,差異有統計學意義(P<0.05);接受冠狀動脈介入術後的急性梗死患者的各指標與對照組研究對象相比無差異(P <0.05)。IL-6水平 P 選擇素濃度低于榦預前(P <0.05);接受冠脈介入術的急性心肌梗死患者的 MMP-9、IL-6水平 P 選擇素比對照組患者相應指標降低更加明顯(P <0.05)。結論急性心肌梗死患者接受冠脈介入榦預可以降低機體 MMP-9和 P 選擇素水平,升高 IL-6水平,改善病人心功能,具有一定的臨床意義。
목적:측정연구대상적혈장 MMP、IL-6화 Ps 수평,분석탐토관상동맥개입술간예전후급성심기경사환자MMP-9、IL-6급 P 선택소변화적림상의의。방법선택본원수치적68례림상접수관상동맥개입간예적급성심기경사환자작위관맥개입수술조,동시선택동기본원건강체검자66례작위대조조,채용매련면역흡부법측정연구대상개입간예전후 MMP-9、IL-6수평화 P 선택소수평。결과급성심기경사환자간예전 MMP-9(704.03±122.54)화 P 선택소(192.34±103.51)현저고우대조조적(312.67±82.79)화(121.27±69.13)、IL-6(50.62±11.17)저우대조조적(71.38±15.75)(P <0.05);관상동맥개입술간예전후,급성심기경사환자적각지표발생변화,차이유통계학의의(P<0.05);접수관상동맥개입술후적급성경사환자적각지표여대조조연구대상상비무차이(P <0.05)。IL-6수평 P 선택소농도저우간예전(P <0.05);접수관맥개입술적급성심기경사환자적 MMP-9、IL-6수평 P 선택소비대조조환자상응지표강저경가명현(P <0.05)。결론급성심기경사환자접수관맥개입간예가이강저궤체 MMP-9화 P 선택소수평,승고 IL-6수평,개선병인심공능,구유일정적림상의의。
Objective Study on the determination of plasma MMP,IL-6 and Ps,to explore Clinical significance of plasm MMP-9、IL-6 and PS in acute myocardial infarction before and after PCI.Methods 68 cases of acute myocardial infarction undergoing coronaryartery interventionaltherapy were selected as coronary intervention operation group,66 cases of healthy people were selected as control group,ELISA was used to test the research object before and after in-terventional therapy of.plasma MMP-9,IL-6 levels and Ps.Results Treatment of patients with acute myocardial in-farction before and?after treatment in two groups of plasma MMP-9(704.03±122.54)and Ps(192.34±103.51)?was significantly higher than that in control group (312.67±82.79)and(121.276±9.13),IL-6(50.62±11.17)was lower than the control group (71.38±15.75)(P <0.05);Before and after coronary artery intervention therapy in patients with acute myocardial infarction,the index changes,the difference has statistical signi-ficance(P <0.05);The indexes of acute infarction after coronary artery intervention compared with the control group had no difference in research ob-jects(P < 0.05).Conclusion Patients with acute myocardial infarction after coronary interventional therapy can de-crease the plasma MMP-9 and Ps,Elevated levels of IL-6,Improve heart function of patients,has certain clinical signifi-cance.