CAJ | 학술논문

目的：探讨白细胞介素1A（IL-1A）多态性与神经胶质瘤的相关性。方法采用聚合酶链反应-限制性片段长度多态性检测154例神经胶质瘤患者和195例正常对照组 IL-1A 多态性。结果IL-1A＋4845G/T 位点：与 GG 基因型相比，GT/TT 基因型显著增加了神经胶质瘤的发病风险（GT/TT 与 GG 相比：χ2＝5．94，P ＝0．015）。与 G 等位基因相比，T 等位基因显著增加了神经胶质瘤的发病风险（χ2＝5．97，P ＝0．015）。未发现 IL-1A-889C/T 多态性频率分布在对照组和神经胶质瘤组之间存在显著差异。根据神经胶质瘤病理分级进行亚组分析，未发现 IL-1A-889C/T 和＋4845G/T 多态性与病理分级存在明显相关性（P ＞0．05）。结论IL-1A ＋4845G/T 多态性与神经胶质瘤的发病有关。
목적：탐토백세포개소1A（IL-1A）다태성여신경효질류적상관성。방법채용취합매련반응-한제성편단장도다태성검측154례신경효질류환자화195례정상대조조 IL-1A 다태성。결과IL-1A＋4845G/T 위점：여 GG 기인형상비，GT/TT 기인형현저증가료신경효질류적발병풍험（GT/TT 여 GG 상비：χ2＝5．94，P ＝0．015）。여 G 등위기인상비，T 등위기인현저증가료신경효질류적발병풍험（χ2＝5．97，P ＝0．015）。미발현 IL-1A-889C/T 다태성빈솔분포재대조조화신경효질류조지간존재현저차이。근거신경효질류병리분급진행아조분석，미발현 IL-1A-889C/T 화＋4845G/T 다태성여병리분급존재명현상관성（P ＞0．05）。결론IL-1A ＋4845G/T 다태성여신경효질류적발병유관。
Objective To investigate the association between interleukin-1A (IL-1A)polymorphisms and risk of gli-oma.Methods The IL-1A polymorphisms were genotyped in 154 patients with glioma and 195 healthy controls using polymerase chain reaction-restriction fragment length polymorphism assay.Results The GT/TT genotypes of IL-1A+4845G/T polymorphism were associated with a significantly increased risk of glioma compared with the GG genotype (GT/TT vs.GG:χ2 =5.94,P =0.015).Similarly,the T allele of IL-1A +4845G/T polymorphism was associated with a significantly increased risk of glioma compared with the G allele (χ2 =5.97,P =0.015).There was no difference in the distribution of the IL-1A-889C/T polymorphism between cases and controls.After subgroup analysis according to histophthological grades,no significant association was observed between IL-1A-889C/T and + 4845G/T polymor-phisms and histophthological grades (P >0.05).Conclusion IL-1A +4845G/T polymorphism is related to the risk of glioma.