中国实验诊断学
中國實驗診斷學
중국실험진단학
CHINESE JOURNAL OF LABORATORY DIAGNOSIS
2014年
9期
1440-1443
,共4页
血管内皮生长因子%慢性阻塞性肺疾病%急性加重期%诊断%预后
血管內皮生長因子%慢性阻塞性肺疾病%急性加重期%診斷%預後
혈관내피생장인자%만성조새성폐질병%급성가중기%진단%예후
vascular endothelial growth factor%chronic obstructive pulmonary disease%acute exacerbation%diagno-sis%prognosis
目的：探讨血管内皮生长因子在慢性阻塞性肺疾病（COPD）急性加重期诊断中的应用及预后的评估价值。方法选取2012年3月-2013年3月我院收治的慢性阻塞性肺疾病稳定期患者15例为稳定组，急性加重期患者30例（脓痰组15例和非脓痰组15例）为加重组，选取同期15例健康者为对照组，在入院24小时内检测各组的血管内皮生长因子（VEGF）、超敏 C-反应蛋白（hs-CRP）、白细胞（WBC）、血清降钙素原（PCT），记录第8天加重组以上指标变化情况，记录加重组患者入院24小时内及治疗第8天急性生理与慢性生理健康状况评分系统Ⅲ（APACHEIII）评分。结果加重组24小时内 VEGF 水平显著高于稳定组，而稳定组又显著高于对照组，差异具有统计学意义（P ＜0．05）；VEGF 的敏感度为86．7％，特异度60％，脓痰组24小时内 VEGF 水平显著高于非脓痰组，两组比较差异具有统计学意义（P ＜0．05）；加重组 VEGF 水平和 APACHEIII 评分具有正相关关系。结论VEGF 是 COPD 急性加重期的一个敏感指标，可以反映病情的预后。
目的：探討血管內皮生長因子在慢性阻塞性肺疾病（COPD）急性加重期診斷中的應用及預後的評估價值。方法選取2012年3月-2013年3月我院收治的慢性阻塞性肺疾病穩定期患者15例為穩定組，急性加重期患者30例（膿痰組15例和非膿痰組15例）為加重組，選取同期15例健康者為對照組，在入院24小時內檢測各組的血管內皮生長因子（VEGF）、超敏 C-反應蛋白（hs-CRP）、白細胞（WBC）、血清降鈣素原（PCT），記錄第8天加重組以上指標變化情況，記錄加重組患者入院24小時內及治療第8天急性生理與慢性生理健康狀況評分繫統Ⅲ（APACHEIII）評分。結果加重組24小時內 VEGF 水平顯著高于穩定組，而穩定組又顯著高于對照組，差異具有統計學意義（P ＜0．05）；VEGF 的敏感度為86．7％，特異度60％，膿痰組24小時內 VEGF 水平顯著高于非膿痰組，兩組比較差異具有統計學意義（P ＜0．05）；加重組 VEGF 水平和 APACHEIII 評分具有正相關關繫。結論VEGF 是 COPD 急性加重期的一箇敏感指標，可以反映病情的預後。
목적：탐토혈관내피생장인자재만성조새성폐질병（COPD）급성가중기진단중적응용급예후적평고개치。방법선취2012년3월-2013년3월아원수치적만성조새성폐질병은정기환자15례위은정조，급성가중기환자30례（농담조15례화비농담조15례）위가중조，선취동기15례건강자위대조조，재입원24소시내검측각조적혈관내피생장인자（VEGF）、초민 C-반응단백（hs-CRP）、백세포（WBC）、혈청강개소원（PCT），기록제8천가중조이상지표변화정황，기록가중조환자입원24소시내급치료제8천급성생리여만성생리건강상황평분계통Ⅲ（APACHEIII）평분。결과가중조24소시내 VEGF 수평현저고우은정조，이은정조우현저고우대조조，차이구유통계학의의（P ＜0．05）；VEGF 적민감도위86．7％，특이도60％，농담조24소시내 VEGF 수평현저고우비농담조，량조비교차이구유통계학의의（P ＜0．05）；가중조 VEGF 수평화 APACHEIII 평분구유정상관관계。결론VEGF 시 COPD 급성가중기적일개민감지표，가이반영병정적예후。
Objective To study the the value of vascular endothelial growth factor for the diagnosis and prognostic evaluation in acute exacerbation of chronic obstructive pulmonary disease.Methods 15 cases of patients with stable chronic obstructive pulmonary disease during stable phase from March 2012 to March 2013 in our hospital were selected as the stabilization group,30 cases with acute exacerbation (15 cases of thick phlegm group and 15 cases of non phlegm group)were selected as the exacerbation group,15 cases of healthy people were selected as the control group,vascular endothelial growth factor (VEGF),high sensitive C-reactive protein (hs-CRP),white blood cell(WBC),serum pro-calcitonin (PCT)of the exacerbation group,stabilization group and the control group were measured in 24 hours after admission,and recorded the above index of the exacerbation group at 8th day and its acute physiology and chronic health evaluation III (APACHEIII )within 24 hours and 8th day of treatment.Results VEGF in the exacerbation group was significantly higher than that in the stabilization group within twenty-fourth hours,and the stabilization group was significantly higher than that in control group,the difference was significant (P <0.05);The sensitivity of VEGF index was 86.7%,the specificity was 60%,VEGF in the thick phlegm group was significantly higher than that in the non phlegm group within twenty-fourth hours,there was statistically significant difference between the two groups (P <0.05);VEGF level and APACHEIII score of the exacerbation group had a positive correlation.Conclusion Vascular endothelial growth factor is a sensitive indicator for acute exacerbation of chronic obstructive pulmonary disease,it can reflect the severity of the disease and its prognosis.
