CAJ | 학술논문

目的：探讨131 I-chTNT 对淋巴瘤细胞的抑制作用，为淋巴瘤的临床治疗提供新策略。方法体外培养人淋巴瘤细胞 Raji 细胞系，应用131 I-chTNT、131 I 以及生理盐水处理淋巴瘤 Raji 细胞，FCM 技术检测细胞凋亡的变化。结果131 I-chTNT 治疗组与131 I 治疗组和空白对照组相比，FCM 显示凋亡率明显增高。结论131 I-chTNT 可诱导淋巴瘤细胞凋亡、抑制淋巴瘤细胞增殖。
목적：탐토131 I-chTNT 대림파류세포적억제작용，위림파류적림상치료제공신책략。방법체외배양인림파류세포 Raji 세포계，응용131 I-chTNT、131 I 이급생리염수처리림파류 Raji 세포，FCM 기술검측세포조망적변화。결과131 I-chTNT 치료조여131 I 치료조화공백대조조상비，FCM 현시조망솔명현증고。결론131 I-chTNT 가유도림파류세포조망、억제림파류세포증식。
Objective To explore the effect on apoptosis of 131 I-chTNT in human lymphoma Raji cells,trying to pro-vide a new treatment strategy for Non-Hodgkins lymphoma.Methods Human lymphoma Raji cells were cultured and were divided into 3 groups,given 131 I-chTNT,131 I and saline,respectively.Cells were collected and measured by flow cy-tometry with PI staining.Results The apoptosis rates of 131 I-chTNT,131 I and saline group were 13.61%,1.62% and 1%,respectively.The apoptosis rate of 131 I-chTN group is higher than other groups (P <0.05).Conclusion 131 I-chT-NT can induct Raji cells’apoptosis,and can also inhibit Raji cells’proliferation.