CAJ | 학술논문

目的：分析血清Ⅲ型前胶原( PCⅢ)的测定在肝纤维化诊断中的应用价值。方法选取121例处于不同炎症进展期的病毒性肝炎患者的标本，采用放射免疫法( RIA )测定血清中的PCⅢ水平，比较各组肝病患者之间及健康献血者血清PCⅢ差异，结合病理结果进行分析。结果血清PCⅢ水平在肝炎各组及肝硬化不同病理分期的差异均有统计学意义(P＜0.05)，在慢性肝炎中度患者明显升高，以慢性肝炎重度、肝硬化者为最高，其升高程度与肝纤维化及肝病严重程度呈正相关。结论血清PCⅢ水平与肝纤维化程度相关，可作为反映慢性肝病肝纤维化严重程度的指标。
목적：분석혈청Ⅲ형전효원( PCⅢ)적측정재간섬유화진단중적응용개치。방법선취121례처우불동염증진전기적병독성간염환자적표본，채용방사면역법( RIA )측정혈청중적PCⅢ수평，비교각조간병환자지간급건강헌혈자혈청PCⅢ차이，결합병리결과진행분석。결과혈청PCⅢ수평재간염각조급간경화불동병리분기적차이균유통계학의의(P＜0.05)，재만성간염중도환자명현승고，이만성간염중도、간경화자위최고，기승고정도여간섬유화급간병엄중정도정정상관。결론혈청PCⅢ수평여간섬유화정도상관，가작위반영만성간병간섬유화엄중정도적지표。
Objective To explore the application value of serum procollagen type Ⅲ (PCⅢ)m easurem ent in hepatic fibrosis diagnosis. Methods 121 sufferers w ith viral hepatitis in different progressive stages w ere selected to be the sam ples,and PCⅢ levels w ere m easured by radioim m unoassay(R IA ),then com pared the differences of PCⅢ in serum of liver disease sufferers and in healthy blood donors,and the data w ere analyzed w ith pathological results.Results The differences of serum PCⅢ levels in sufferers w ith hepatitis and liver cirrhosis in pathological stages w ere of statistical significance(P<0.05).Serum PCⅢ levels clearly rose in sufferers w ith m oderate chronic hepatitis, w ith the highest in sufferers w ith severe chronic hepatitis and liver cirrhosis.T he increased degree w as positively related to the degree of hepatic fibrosis and severity of liver diseases.Conclusion Serum PCⅢ levels are related to the degree of hepatic fibrosis,w hich can be taken as an index to reflect the severity level of hepatic fibrosis in chronic liver diseases.