CAJ | 학술논문

Bcl-2家族是细胞凋亡过程中关键的凋亡调节因子，包括抑制和促进凋亡两类蛋白。Bcl-2家族蛋白成员间的相互作用对线粒体介导的细胞凋亡信号通路具有调控作用。Bcl-2家族成员的表达异常与肿瘤的发生、发展以及耐药性密切相关。现就Bcl-2家族的研究进展作一综述。
Bcl-2가족시세포조망과정중관건적조망조절인자，포괄억제화촉진조망량류단백。Bcl-2가족단백성원간적상호작용대선립체개도적세포조망신호통로구유조공작용。Bcl-2가족성원적표체이상여종류적발생、발전이급내약성밀절상관。현취Bcl-2가족적연구진전작일종술。
B cl-2 fam ily proteins are im portant apoptosis regulatory factors during cell apoptosis that include tw o kinds of protein w ith suppression and prom otion .T he interaction betw een B cl-2 fam ily protein m em bers can regulate m itochondria m ediated cell apoptosis signal-ing pathw ays.A bnorm al expression of B cl-2 fam ily m em bers are closely related to the occurrence,developm ent and drug resistance of tu-m or.This article sum m arizes the reseach progress of Bcl-2 fam ily.