CAJ | 학술논문

目的：观察矽肺患者诱导痰中一氧化氮( NO )、丙二醛( MDA )水平，了解NO和MDA水平在矽肺发生发展中的作用，探讨检测矽肺患者诱导痰中NO和MDA水平的意义。方法以50名某酒店服务人员为对照人群，50名接触矽尘1年以上的接尘工人为接尘组，52例矽肺患者为矽肺组，采用酶联免疫吸附试验( ELISA )法进行诱导痰中NO和MDA水平测定。结果与对照组比较，接尘组和矽肺组NO水平明显升高，差异均有高度统计学意义(P＜0.01)，与对照组及接尘组比较，矽肺组MDA水平明显升高，差异均有统计学意义(P＜0.05)，观察对象组与各期矽肺的NO、MDA水平的比较，差异均无统计学意义。结论机体氧化和抗氧化系统的失衡与矽肺的发生发展有关；对氧化应激指标的监测有利于预测矽肺发病和评估预后。
목적：관찰석폐환자유도담중일양화담( NO )、병이철( MDA )수평，료해NO화MDA수평재석폐발생발전중적작용，탐토검측석폐환자유도담중NO화MDA수평적의의。방법이50명모주점복무인원위대조인군，50명접촉석진1년이상적접진공인위접진조，52례석폐환자위석폐조，채용매련면역흡부시험( ELISA )법진행유도담중NO화MDA수평측정。결과여대조조비교，접진조화석폐조NO수평명현승고，차이균유고도통계학의의(P＜0.01)，여대조조급접진조비교，석폐조MDA수평명현승고，차이균유통계학의의(P＜0.05)，관찰대상조여각기석폐적NO、MDA수평적비교，차이균무통계학의의。결론궤체양화화항양화계통적실형여석폐적발생발전유관；대양화응격지표적감측유리우예측석폐발병화평고예후。
Objective To observe the nitric oxide (NO)and m alondialdehyde (MDA )levels in induced sputum of silicosis sufferers and their role in the developm ent of silicosis to explore the significance of testing NO and MDA levels in silicosis sufferers.Methods Fifty hotel staff w ere chosen as control group,w hile 50 w orkers w ith m ore than one year exposure to silica dust as exposure group,and 52 sili-cosis sufferers as silicosis group.ELISA m ethod was adopted to determ ine the NO and M DA leveslin induced sputum .Results Com pared w ith the control group,NO levels in the exposure group and the silicosis group clearly increased,and the differences w ere of high statisti-cal significance (P<0 .01 ).Com pared w ith the control group and the exposure group ,MDA levels in the silicosis group clearly increased , and the differences w ere of statistical significance(P<0.05).The differences of NO and MDA levels w ere not of statistical significanc be-tw een the control group and the silicosis group of different stages.Conclusion The out-of-balance of organic oxidation and antioxidant system is related to the developm ent of silicosis,so m onitoring the indicators of oxidative stress can help to predict the incidence and as-sess the prognosis of silicosis.