CAJ | 학술논문

目的通过检索和分析相关文献,荟萃相关证据,系统评价小肾癌供肾移植的效果及移植后肿瘤复发风险.方法通过制定完备的检索策略,在PubMed、Embase、Cochrane Library和ClinicalTrials.gov四个数据库中无语言限制地检索相关文献,人工检索入选文献,避免遗漏.2名研究者根据预先制定好的文献纳入和排除标准独立地筛选文献,按预制好的表格提取纳入文献中的相关资料,数据获取后,汇编成表,计算总的肿瘤复发率.结果共有1680篇文献被检索出,通过筛选,最终纳入15个研究,这15个研究均为病例报道或病例系列研究.通过对现有文献的系统综述,目前总共有96例小肾癌肾脏作为供肾用于临床肾移植,移植后受者均未出现肾癌复发或转移.结论小肾癌供肾用于移植后可获得良好的移植效果,肾癌的复发率相对很低,值得进一步深入研究和应用.
목적 통과검색화분석상관문헌,회췌상관증거,계통평개소신암공신이식적효과급이식후종류복발풍험.방법 통과제정완비적검색책략,재PubMed、Embase、Cochrane Library화ClinicalTrials.gov사개수거고중무어언한제지검색상관문헌,인공검색입선문헌,피면유루.2명연구자근거예선제정호적문헌납입화배제표준독입지사선문헌,안예제호적표격제취납입문헌중적상관자료,수거획취후,회편성표,계산총적종류복발솔.결과 공유1680편문헌피검색출,통과사선,최종납입15개연구,저15개연구균위병례보도혹병례계렬연구.통과대현유문헌적계통종술,목전총공유96례소신암신장작위공신용우림상신이식,이식후수자균미출현신암복발혹전이.결론 소신암공신용우이식후가획득량호적이식효과,신암적복발솔상대흔저,치득진일보심입연구화응용.
Objective To review the literature and synthesize current evidence on the use of kidneys with small renal cancer as donor kidneys.Method To locate eligible studies,four bibliographic databases including PubMed,Embase,Cochrane Library and ClinicalTrials.gov were screened,while key informants were collected and bibliographies of included studies were scrutinised.Two reviewers independently assessed studies for inclusion,extracted data.Data were synthesised as a narrative review.Results 1680 articles were found while eventually 15 studies were selected for this systematic review.All of the 15 included studies were case reports or case series.Totally 96 documented cases of donor kidneys after resection of small renal cancer were transplanted and no definite recurrence happened.Conclusion It is suggested from current limited evidence that cancer recurrence rate of allotransplanting kidney after resection of SRC was relatively low,thus it deserved much more well-designed clinical trials and clinical use.