CAJ | 학술논문

目的建立顶空气相色谱法测定布洛芬缓释胶囊中乙醇残留量。方法采用Agilent HP-FFAP（30 m×0.320 m，0.25μm ）毛细管柱为色谱柱，柱温为40℃，进样口温度为150℃，FID检测器温度为250℃，顶空瓶平衡温度为85℃，平衡时间为30 min，进样量1 mL，载气为氮气，流速2.0 mL/min。结果乙醇在0.05036～2.0144 mg/mL范围内呈良好线性关系（r=0.9997，n=6），平均回收率（n=9）为100.9%（RSD为0.24%）。结论本法简便、准确，重复性好，专属性强，灵敏度高，可用于布洛芬缓释胶囊中乙醇残留量的测定。
목적건립정공기상색보법측정포락분완석효낭중을순잔류량。방법채용Agilent HP-FFAP（30 m×0.320 m，0.25μm ）모세관주위색보주，주온위40℃，진양구온도위150℃，FID검측기온도위250℃，정공병평형온도위85℃，평형시간위30 min，진양량1 mL，재기위담기，류속2.0 mL/min。결과을순재0.05036～2.0144 mg/mL범위내정량호선성관계（r=0.9997，n=6），평균회수솔（n=9）위100.9%（RSD위0.24%）。결론본법간편、준학，중복성호，전속성강，령민도고，가용우포락분완석효낭중을순잔류량적측정。
Objective To determine the residual ethanol in ibuprofen sustained release capsule by headspace gas chromatography.Methods Agilent HP-FFAP(30 m×0.320 m,0.25μm) was used.The column temperature was 40℃. The injection port temperature was 150 ℃ .The FID detector temperature was 250 ℃ .The equilibrium temperature of the headspace gas bottle was 85 ℃ .The equilibrium time was 30 minutes.The injection volume was 1 mL.The Carrier gas was nitrogen.The flow rate was 1.0 mL/min. Results A good linear correlation of ethanol was observed within the range of 0.05036-2.0144 mg/mL(r=0.9997,n=6). The average recovery was 100.9% with RSD 0.24%(n=9). Conclusion The method is simple,accurate and repeatable,with strong selectivity and high sensitivity.It can be applied to the determination of of residual ethanol in ibuprofen sustained release capsule.