CAJ | 학술논문

　　目的监测儿童呼吸道合胞病毒（RSV），探讨其流行规律。方法应用直接免疫荧光法检测2007年1月-2011年12月间收集的28871份急性呼吸道感染住院患儿鼻咽分泌物标本的RSV病毒抗原；同时分析RSV阳性检出率与同期月平均气温等气象资料的相关性。结果2007-2010年苏州地区RSV感染主要集中在冬春季，而2011年从7月起即现高发趋势；2007-2008年、2008-2009年、2009-2010年、2010-2011年冬春RSV阳性检出率分别为38.57%、19.86%、29.73%、30.79%，差异有统计学意义（χ2=176.85，P<0.001）；2011年7-9月份阳性检出率分别为5.74%、21.09%和31.15%，与前4年同期的差异也有统计学意义（χ2=8.06~405.43，P均<0.05）；RSV检出率与月平均气温、月雨量、月日照时间及风速呈负相关（r=-0.799~-0.214，P均<0.05）。经多元逐步回归分析，仅气温对RSV检出率影响有统计学意义（P=0.001）。结论 RSV仍是苏州地区冬春季婴幼儿下呼吸道感染主要病毒病原，RSV检出率与该地区气候因素有关。
　　목적감측인동호흡도합포병독（RSV），탐토기류행규률。방법응용직접면역형광법검측2007년1월-2011년12월간수집적28871빈급성호흡도감염주원환인비인분비물표본적RSV병독항원；동시분석RSV양성검출솔여동기월평균기온등기상자료적상관성。결과2007-2010년소주지구RSV감염주요집중재동춘계，이2011년종7월기즉현고발추세；2007-2008년、2008-2009년、2009-2010년、2010-2011년동춘RSV양성검출솔분별위38.57%、19.86%、29.73%、30.79%，차이유통계학의의（χ2=176.85，P<0.001）；2011년7-9월빈양성검출솔분별위5.74%、21.09%화31.15%，여전4년동기적차이야유통계학의의（χ2=8.06~405.43，P균<0.05）；RSV검출솔여월평균기온、월우량、월일조시간급풍속정부상관（r=-0.799~-0.214，P균<0.05）。경다원축보회귀분석，부기온대RSV검출솔영향유통계학의의（P=0.001）。결론 RSV잉시소주지구동춘계영유인하호흡도감염주요병독병원，RSV검출솔여해지구기후인소유관。
Objectives To investigate the epidemiological feature of respiratory syncytial virus (RSV) in hospitalized children with acute respiratory infection. Methods A total of 28 871 children with acute respiratory tract infection from Janu-ary 2007 to December 2011 were enrolled in the study. Nasopharyngeal aspirates were obtained from the respiratory tract by aseptic vacuum aspiration. Direct immuno-lfuorescence assay was used to detect RSV antigen. Correlation between RSV posi-tive rate and meteorological data including mean air temperature and total monthly rainfall, etc. was analyzed. Results The peak infection seasons of RSV during 2007-2010 were winter and spring in Suzhou, while in 2011 the infection rate of RSV was increased since July. The positive rates of RSV during winter and spring in 2007-2008, 2008-2009, 2009-2010 and 2010-2011 were 38.57%, 19.86%, 29.73%and 30.79%, respectively, with signiifcant difference (χ2=176.85, P<0.001). From July to September in 2011, the positive rate of RSV was 5.74%, 21.09%and 31.15%, respectively, higher than that of the same period from 2007 to 2010 (χ2=8.06~405.43, all P<0.05). The positive rate of RSV was negatively correlated with mean temperature, volume of rainfall, duration of sunshine and wind velocity (r=-0.799~-0.214, all P<0.05). Only mean temperature had a signiifcant impact on RSV activity by a stepwise multiple regression (P<0.001). Conclusions The date indicated that RSV was still an important etiological agent for acute lower respiratory infection in infants and young children in Suzhou area during winter and spring. The incidence of RSV was associated with the climate in Suzhou.