CAJ | 학술논문

目的探讨高胆红素血症对人类听通路的影响，为临床高胆患儿的早期干预提供理论依据。方法根据新生儿血清胆红素浓度峰值分为高胆红素Ⅰ组（高胆Ⅰ组），血清胆红素220~342μmol/L，56例；高胆Ⅱ组，血清高胆红素＞342μmol/L，18例；另选择同期住院的无黄疸新生儿为对照组，30例。观察高胆Ⅰ组、Ⅱ组与对照组患儿脑干听觉诱发电位（BAEP）及Ⅰ组、Ⅱ组治疗前后BAEP的变化。结果高胆Ⅰ组、Ⅱ组BAEP的Ⅰ、Ⅲ、Ⅴ波峰潜伏期（PL）及Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ波峰间潜伏期（IPL）比对照组均明显延长，差异均有统计学意义（均P＜0.01）；而高胆Ⅱ组又比高胆Ⅰ组明显延长，差异均有统计学意义（P＜0.05或0.01）；高胆Ⅰ组、Ⅱ组治疗后,这些指标比治疗前明显缩短，差异均有统计学意义（P＜0.05或0.01）。结论高胆可致新生儿BAEP异常，重度高胆BAEP异常更明显，早期干预可逆转异常BAEP。
목적탐토고담홍소혈증대인류은통로적영향，위림상고담환인적조기간예제공이론의거。방법근거신생인혈청담홍소농도봉치분위고담홍소Ⅰ조（고담Ⅰ조），혈청담홍소220~342μmol/L，56례；고담Ⅱ조，혈청고담홍소＞342μmol/L，18례；령선택동기주원적무황달신생인위대조조，30례。관찰고담Ⅰ조、Ⅱ조여대조조환인뇌간은각유발전위（BAEP）급Ⅰ조、Ⅱ조치료전후BAEP적변화。결과고담Ⅰ조、Ⅱ조BAEP적Ⅰ、Ⅲ、Ⅴ파봉잠복기（PL）급Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ파봉간잠복기（IPL）비대조조균명현연장，차이균유통계학의의（균P＜0.01）；이고담Ⅱ조우비고담Ⅰ조명현연장，차이균유통계학의의（P＜0.05혹0.01）；고담Ⅰ조、Ⅱ조치료후,저사지표비치료전명현축단，차이균유통계학의의（P＜0.05혹0.01）。결론고담가치신생인BAEP이상，중도고담BAEP이상경명현，조기간예가역전이상BAEP。
Objective To explore the influence of auditory pathways that was caused by hyperbilirubinemia in the neonates,and provide evidences for prediction of outcome. Methods Total y hospitalized patients with hyperbilirubinemia were divided into two groups:(1)Group A, total serum bilirubin(TSB) between 220~342μmol/L;(2)Group B, TSB>342μmol/L;Group C, normal neonates were included as controls. Observe the difference of BAEP between abnormal and normal neonates and the change of BAEP in al abnormal cases before and after treatment. Results Compared to the control group(30), the PL(Ⅰ、Ⅲ、Ⅴ) and IPL(Ⅰ~Ⅲ、Ⅲ~Ⅴ、Ⅰ~Ⅴ) of abnormal BAEP were prolonger in group A(56)and group B(18), the difference being very sig-nificant(P<0.01). Compared to the group A, the PL(Ⅰ、Ⅲ、Ⅴ) and IPL(Ⅰ~Ⅲ、Ⅲ~Ⅴ、Ⅰ~Ⅴ) of BAEP were prolonger in group B, the difference being very significant(P<0.05 or 0.01). After treatment, the PL(Ⅰ、Ⅲ、Ⅴ) and IPL(Ⅰ~Ⅲ、Ⅲ~Ⅴ、Ⅰ~Ⅴ) of abnor-mal BAEP were shorter in group A and group B, the difference being very significant (P<0.05 or 0.01). Conclusion Hyperbiliru-binemia can cause the abnormal BAEP, and the feature of abnormal BAEP in severe hyperbilirubinemia neonates was much more obvious. The early treatment can reverse the abnormal BAEP.