浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2013年
16期
1502-1504,1515
,共4页
马莉亚%东丽丽%卢美萍%陈志敏
馬莉亞%東麗麗%盧美萍%陳誌敏
마리아%동려려%로미평%진지민
腺病毒%呼吸道感染%儿童
腺病毒%呼吸道感染%兒童
선병독%호흡도감염%인동
Adenovirus%Respiratory tract infection%Children
目的了解杭州地区儿童下呼吸道腺病毒(ADV)感染流行情况。方法因急性下呼吸道感染( ALRTI)住院的患儿共76518例,所有ALRTI患儿的鼻咽分泌物均采用直接免疫荧光法作腺病毒等7种病毒的病原学测定。结果76518例标本中ADV阳性479例,阳性率0.63%;男∶女为2.24∶1;年龄中位数16个月(1~172个月),年龄<6个月39例(8.14%),~24个月265例(55.32%),~36个月66例(13.78%),~60个月72例(15.03%),>60个月37例(7.72%)。春季176例(36.74%),夏季124例(25.89%),秋季51例(10.65%),冬季128例(26.72%),冬、春、夏季发病率明显高于秋季,差异均有统计学意义(P<0.05或0.01)。冬、春、夏季节之间比较,差异无统计学意义。从2007-2012年春季ADV阳性患儿占同期所有ALRTI患儿的构成比分别为18.01‰,5.73‰,11.85‰,6.35‰,11.77‰,2.66‰,存在每2年1次的流行趋势。结论杭州地区儿童下呼吸道ADV感染全年散发,以冬、春、夏季为主,可能存在每2年1次的春季小流行。6~24个月为感染高峰年龄。
目的瞭解杭州地區兒童下呼吸道腺病毒(ADV)感染流行情況。方法因急性下呼吸道感染( ALRTI)住院的患兒共76518例,所有ALRTI患兒的鼻嚥分泌物均採用直接免疫熒光法作腺病毒等7種病毒的病原學測定。結果76518例標本中ADV暘性479例,暘性率0.63%;男∶女為2.24∶1;年齡中位數16箇月(1~172箇月),年齡<6箇月39例(8.14%),~24箇月265例(55.32%),~36箇月66例(13.78%),~60箇月72例(15.03%),>60箇月37例(7.72%)。春季176例(36.74%),夏季124例(25.89%),鞦季51例(10.65%),鼕季128例(26.72%),鼕、春、夏季髮病率明顯高于鞦季,差異均有統計學意義(P<0.05或0.01)。鼕、春、夏季節之間比較,差異無統計學意義。從2007-2012年春季ADV暘性患兒佔同期所有ALRTI患兒的構成比分彆為18.01‰,5.73‰,11.85‰,6.35‰,11.77‰,2.66‰,存在每2年1次的流行趨勢。結論杭州地區兒童下呼吸道ADV感染全年散髮,以鼕、春、夏季為主,可能存在每2年1次的春季小流行。6~24箇月為感染高峰年齡。
목적료해항주지구인동하호흡도선병독(ADV)감염류행정황。방법인급성하호흡도감염( ALRTI)주원적환인공76518례,소유ALRTI환인적비인분비물균채용직접면역형광법작선병독등7충병독적병원학측정。결과76518례표본중ADV양성479례,양성솔0.63%;남∶녀위2.24∶1;년령중위수16개월(1~172개월),년령<6개월39례(8.14%),~24개월265례(55.32%),~36개월66례(13.78%),~60개월72례(15.03%),>60개월37례(7.72%)。춘계176례(36.74%),하계124례(25.89%),추계51례(10.65%),동계128례(26.72%),동、춘、하계발병솔명현고우추계,차이균유통계학의의(P<0.05혹0.01)。동、춘、하계절지간비교,차이무통계학의의。종2007-2012년춘계ADV양성환인점동기소유ALRTI환인적구성비분별위18.01‰,5.73‰,11.85‰,6.35‰,11.77‰,2.66‰,존재매2년1차적류행추세。결론항주지구인동하호흡도ADV감염전년산발,이동、춘、하계위주,가능존재매2년1차적춘계소류행。6~24개월위감염고봉년령。
Objective To study the epidemiological characteristics on adenovirus(ADV) infection in children with acute low respiratory tract infection (ALRTI) in Hangzhou city. Methods Nasopharyngeal secretion (NPS) samples were collected from 76,518 hospitalized patients with ALRTI at Children's Hospital of Zhejiang University School of Medicine from July 2006 to June 2012. The antigen expressions of 7 viruses including ADV in NPS samples were detected by direct immunofluorescence assays (DFA). Results Total 479 samples showed positive for ADV accounting for 0.63%(479/76 518)of al samples. The median age of patients was 16 months(1~172 months) and the male/female ratio was 2.24:1. The case distribution in each age group was as fol-lows:39 (8.14%)<6months, 265 (55.32%)~24 months, 66 (13.78%)~36months, 72 (15.03%)~60months and 37 (7.72%)≥60 months. The season distribution showed that 176 cases in spring (36.74%), 124 in summer (25.89%), 51 in autumn (10.65%) and 128 in winter(26.72%). The morbidity in autumn was significantly lower than that in other three seasons(P<0.05 or 0.01);however, there was no significant difference among spring, summer and winter seasons. The patients with ADV infection in ALRTI cases accounted for 18.01‰, 5.73‰, 11.85‰, 6.35‰ and 2.66‰in spring from 2007 to 2011, indicating a biennial epidemic tendency. Conclusion ADV infection is relatively common in Hangzhou city, demonstrating a gender, age and season variation s in children with ALRTI.