CAJ | 학술논문

目的探讨激活素A（ACTA）、抑制素A（INHA）在子宫内膜异位症（EMS）内膜的表达及其临床意义。方法收集30例EMS患者（EMS组）在位内膜及异位内膜组织，其中增生期16例，分泌期14例。同期正常子宫内膜患者30例为对照组。采用免疫组织化学链霉素抗生物蛋白-过氧化物酶法检测两组内膜ACTA、INHA的表达；电化学发光法检测两组血清性激素E2、P水平。结果（1）EMS组在位内膜、异位内膜ACTA、INHA表达水平均明显高于对照组（均P＜0.05）。（2）EMS组在位内膜增生期、分泌期ACTA、INHA表达水平的差异均无统计学意义（均P＞0.05）。（3）EMS组在位内膜增生期、分泌期ACTA、INHA表达水平与E2、P水平均无相关性（均P＞0.05）。对照组增生期ACTA、INHA表达水平均与E2水平呈正相关（均P＜0.05）；对照组分泌期ACTA、INHA表达水平与E2、P水平均呈正相关（均P＜0.05）。结论 ACTA、INHA在EMS表达增强，提示ACTA、INHA可能参与EMS的发生。
목적탐토격활소A（ACTA）、억제소A（INHA）재자궁내막이위증（EMS）내막적표체급기림상의의。방법수집30례EMS환자（EMS조）재위내막급이위내막조직，기중증생기16례，분비기14례。동기정상자궁내막환자30례위대조조。채용면역조직화학련매소항생물단백-과양화물매법검측량조내막ACTA、INHA적표체；전화학발광법검측량조혈청성격소E2、P수평。결과（1）EMS조재위내막、이위내막ACTA、INHA표체수평균명현고우대조조（균P＜0.05）。（2）EMS조재위내막증생기、분비기ACTA、INHA표체수평적차이균무통계학의의（균P＞0.05）。（3）EMS조재위내막증생기、분비기ACTA、INHA표체수평여E2、P수평균무상관성（균P＞0.05）。대조조증생기ACTA、INHA표체수평균여E2수평정정상관（균P＜0.05）；대조조분비기ACTA、INHA표체수평여E2、P수평균정정상관（균P＜0.05）。결론 ACTA、INHA재EMS표체증강，제시ACTA、INHA가능삼여EMS적발생。
Objective To investigate the expression of activin A(ACTA) and inhibin A(INHA) in endometriosis and its clinical significance. Methods Eutopic and ectopic endometrial tissues were col ected from women with endometriosis (ectopic group, n=30), among which, sixteen samples were in proliferative phase and the other were in secretory phase. Normal endometrial tis-sues (control group, n=30) were col ected from women without endometriosis. Immunohistochemistry (IHC) SP method was con-ducted to detect the expression of ACTA and INHA. Chemiluminescence assay was performed to measure the expression levels of estrogen (E2) and progestogen (P) in serum of these participants. Results The expression of ACTA and INHA was significantly higher in the ectopic and eutopic endomtria than that in the normal endometrium (both P<0.05). There was no significant differ-ence in ACTA and INHA expression between proliferative and secretory phase in eutopic endometrium (P>0.05). In the prolifera-tive or secretory phase of eutopic group, neither ACTA nor INHA expression was correlated with the level of E2 and P (P>0.05). Positive correlation was shown between expression of ACTA, INHA and E2 (P<0.05) in the proliferative phase of control group;in secretory phase of control group, expressions of ACTA and INHA were positively correlated with E2 (P<0.05) and P (P<0.05). Conclusion The present data suggest that the increased expressions of ACTA and INHA in the eutopic and ectopic endometria of endometriosis patients may participate in the pathogenesis and progression of endometriosis.