CAJ | 학술논문

目的：观察并对比奥沙利铂( L-OHP)分别联合培美曲塞( PEM)、吉西他滨( GEM)化疗方案治疗晚期非小细胞肺癌(NSCLC)的临床疗效。方法将94例晚期NSCLC患者随机分为A、B两组,A组予L-OHP+PEM方案,B组予L-OHP+GEM方案,对比两组临床疗效、药物毒性反应及2年生存率。结果①两组临床疗效构成、药物毒性反应发生率、化疗后2年生存率、病死者平均生存月数相近( P>0．05)；②A组腺癌患者化疗后KPS评分、2年生存率、病死者平均生存月数显著高于B组( P<0．05)。结论两种化疗方案治疗晚期NSCLC疗效相当,L-OHP+PEM方案对腺癌疗效具有比较优势。
목적：관찰병대비오사리박( L-OHP)분별연합배미곡새( PEM)、길서타빈( GEM)화료방안치료만기비소세포폐암(NSCLC)적림상료효。방법장94례만기NSCLC환자수궤분위A、B량조,A조여L-OHP+PEM방안,B조여L-OHP+GEM방안,대비량조림상료효、약물독성반응급2년생존솔。결과①량조림상료효구성、약물독성반응발생솔、화료후2년생존솔、병사자평균생존월수상근( P>0．05)；②A조선암환자화료후KPS평분、2년생존솔、병사자평균생존월수현저고우B조( P<0．05)。결론량충화료방안치료만기NSCLC료효상당,L-OHP+PEM방안대선암료효구유비교우세。
Objective To observe and compare the clinical efficacy of oxaliplatin ( L-OHP) combined with pemetrexed ( PEM) or gemcitabine ( GEM) in the treatment of advanced non-small-cell lung cancer. Methods 94 patients with advanced NSCLC were randomly divided into two groups. The group A was applied with L-OHP+PEM scheme, and the group B was applied with L-OHP + GEM scheme. The clinical efficacy, drug toxicity and 24 months survival rate were compared. Results ① There was no statistical difference in proportion of curative effica-cy, drug toxicities, 2 years survival rate and mean survival times between the two groups (P>0. 05). ② The im-provement of KPS score, 2 years survival rate and mean survival time was more pronounced in adenocarcinoma pa-tients of the group A than those in the group B (P<0. 05). Conclusion The clinical efficacy of L-OHP plus PEM and L-OHP plus GEM is similar, and the former is better to adenocarcinoma patients.