浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2013年
17期
1574-1577
,共4页
糖尿病视网膜病变%基质细胞衍生因子-1(SDF-1)%血管内皮生长因子(VEGF)%血清%2型糖尿病
糖尿病視網膜病變%基質細胞衍生因子-1(SDF-1)%血管內皮生長因子(VEGF)%血清%2型糖尿病
당뇨병시망막병변%기질세포연생인자-1(SDF-1)%혈관내피생장인자(VEGF)%혈청%2형당뇨병
Diabetic retinopathy%Stromal cell- derived factor- 1(SDF- 1)%Vascular endothelial growth factor (VEGF)%Serum%Type 2 diabetes
目的研究2型糖尿病患者血清SDF-1、VEGF水平与糖尿病视网膜病变的相关性，并分析影响血清SDF-1、VEGF水平的因素。方法选取2010-02-04内分泌科及眼科就诊的2型糖尿病患者59例，根据眼底情况分为无糖尿病视网膜病变（NDR）组20例、背景期糖尿病视网膜病变（BDR）组20例、增殖期糖尿病视网膜病变（PDR）组19例。另选取同时期体检中心健康体检者17例为对照（CON）组。采用双抗体夹心酶联免疫吸附法（ELISA法）定量测定血清SDF-1、VEGF水平。记录研究对象的病程、身高、体重、血压，测定空腹血糖（FPG）、糖化血红蛋白（HbA1c）、血清总胆固醇（TC）及肾功能指标。结果 BDR组、PDR组血清SDF-1水平比NDR组、CON组增高，均有统计学差异（均P＜0.01）；PDR组血清中SDF-1水平高于BDR组（P＜0.01）。NDR组、BDR组、PDR组血清VEGF水平明显高于CON组，均有统计学差异（均P＜0.01）；NDR组、BDR组、PDR组3组两两比较血清VEGF水平无统计学差异（均P＞0.05）。相关分析提示各组血清SDF-1水平与VEGF水平呈正相关（P＜0.01），而血清SDF-1水平与患者病程及收缩压相关（均P＜0.01），血清VEGF水平与患者病程、TC水平相关（均P＜0.05）。结论2型糖尿病患者血清中SDF-1水平与血清VEGF水平呈正相关，两者与糖尿病视网膜病变的发生、发展关系密切，与糖尿病病程、收缩压、TC水平存在相关性。
目的研究2型糖尿病患者血清SDF-1、VEGF水平與糖尿病視網膜病變的相關性，併分析影響血清SDF-1、VEGF水平的因素。方法選取2010-02-04內分泌科及眼科就診的2型糖尿病患者59例，根據眼底情況分為無糖尿病視網膜病變（NDR）組20例、揹景期糖尿病視網膜病變（BDR）組20例、增殖期糖尿病視網膜病變（PDR）組19例。另選取同時期體檢中心健康體檢者17例為對照（CON）組。採用雙抗體夾心酶聯免疫吸附法（ELISA法）定量測定血清SDF-1、VEGF水平。記錄研究對象的病程、身高、體重、血壓，測定空腹血糖（FPG）、糖化血紅蛋白（HbA1c）、血清總膽固醇（TC）及腎功能指標。結果 BDR組、PDR組血清SDF-1水平比NDR組、CON組增高，均有統計學差異（均P＜0.01）；PDR組血清中SDF-1水平高于BDR組（P＜0.01）。NDR組、BDR組、PDR組血清VEGF水平明顯高于CON組，均有統計學差異（均P＜0.01）；NDR組、BDR組、PDR組3組兩兩比較血清VEGF水平無統計學差異（均P＞0.05）。相關分析提示各組血清SDF-1水平與VEGF水平呈正相關（P＜0.01），而血清SDF-1水平與患者病程及收縮壓相關（均P＜0.01），血清VEGF水平與患者病程、TC水平相關（均P＜0.05）。結論2型糖尿病患者血清中SDF-1水平與血清VEGF水平呈正相關，兩者與糖尿病視網膜病變的髮生、髮展關繫密切，與糖尿病病程、收縮壓、TC水平存在相關性。
목적연구2형당뇨병환자혈청SDF-1、VEGF수평여당뇨병시망막병변적상관성，병분석영향혈청SDF-1、VEGF수평적인소。방법선취2010-02-04내분비과급안과취진적2형당뇨병환자59례，근거안저정황분위무당뇨병시망막병변（NDR）조20례、배경기당뇨병시망막병변（BDR）조20례、증식기당뇨병시망막병변（PDR）조19례。령선취동시기체검중심건강체검자17례위대조（CON）조。채용쌍항체협심매련면역흡부법（ELISA법）정량측정혈청SDF-1、VEGF수평。기록연구대상적병정、신고、체중、혈압，측정공복혈당（FPG）、당화혈홍단백（HbA1c）、혈청총담고순（TC）급신공능지표。결과 BDR조、PDR조혈청SDF-1수평비NDR조、CON조증고，균유통계학차이（균P＜0.01）；PDR조혈청중SDF-1수평고우BDR조（P＜0.01）。NDR조、BDR조、PDR조혈청VEGF수평명현고우CON조，균유통계학차이（균P＜0.01）；NDR조、BDR조、PDR조3조량량비교혈청VEGF수평무통계학차이（균P＞0.05）。상관분석제시각조혈청SDF-1수평여VEGF수평정정상관（P＜0.01），이혈청SDF-1수평여환자병정급수축압상관（균P＜0.01），혈청VEGF수평여환자병정、TC수평상관（균P＜0.05）。결론2형당뇨병환자혈청중SDF-1수평여혈청VEGF수평정정상관，량자여당뇨병시망막병변적발생、발전관계밀절，여당뇨병병정、수축압、TC수평존재상관성。
Objective To investigate the correlation of serum SDF- 1 and VEGF levels with diabetic retinopathy. Methods Fifty nine patients with type 2 diabetes were enrolled in the study, including 20 cases without diabetic retinopathy (NDR), 20 cases with background diabetic retinopathy (BDR) and 19 cases with proliferative diabetic retinopathy (PDR) , 17 healthy subjects were also included as control group. Serum SDF- 1 and VEGF levels were measured by enzyme- linked immunosorbent assay (ELISA). Blood pressure (BP), glycosylated hemoglobin A1c (Hb), and serum glucose, total cholesterol (TC), triglyceride (TG), and renal function were measured. Results Serum levels of SDF- 1 and VEGF were elevated in 3 subgroups of diabetic patients com-pared to controls (P<0.01). There were significant differences in serum SDF- 1 levels among NDR, BDR and PDR groups (P<0.01). The levels of SDF- 1 and VEGF were positively correlated with each other (r=0.626, P<0.01). Stepwise multiple regression analysis revealed that serum levels of SDF- 1 were correlated with course of diabetes and systolic BP (both P<0.01);VEGF levels were correlated with course of diabetes and TC (both P<0.05). Conclusion Serum SDF- 1 and VEGF are correlated with each other, both are closely related to the development and the disease courses of diabetic retinopathy.
