CAJ | 학술논문

目的探讨Ⅱ~Ⅲ期非小细胞肺癌（NSCLC）患者肿瘤组织中MMP-3和TIMP-3的表达与术后接受含铂药物辅助化疗疗效的相关性。方法应用免疫组化方法检测112例NSCLC患者术后肿瘤组织中MMP-3和TIMP-3的表达，分析与化疗疗效和患者生存资料间的关系。结果患者肿瘤组织中MMP-3阳性率为56.25%，TIMP-3阳性率为47.32%，MMP-3阴性者术后生存优于阳性者；TIMP-3阴性者的术后生存低于阳性者（均P＜0.01)。MMP-3阴性同时TIMP-3阳性的患者术后使用铂类药物辅助化疗，生存时间可能延长。结论 MMP-3和TIMP-3的表达可能作为NSCLC患者术后铂类药物化疗疗效及预后预测的参考指标。
목적탐토Ⅱ~Ⅲ기비소세포폐암（NSCLC）환자종류조직중MMP-3화TIMP-3적표체여술후접수함박약물보조화료료효적상관성。방법응용면역조화방법검측112례NSCLC환자술후종류조직중MMP-3화TIMP-3적표체，분석여화료료효화환자생존자료간적관계。결과환자종류조직중MMP-3양성솔위56.25%，TIMP-3양성솔위47.32%，MMP-3음성자술후생존우우양성자；TIMP-3음성자적술후생존저우양성자（균P＜0.01)。MMP-3음성동시TIMP-3양성적환자술후사용박류약물보조화료，생존시간가능연장。결론 MMP-3화TIMP-3적표체가능작위NSCLC환자술후박류약물화료료효급예후예측적삼고지표。
Objective To investigate the expression of MMP- 3, TIMP- 3 in patients with non- smal cel lung cancer (NSCLC) and its relation to the prognosis after chemotherapy. Methods Expression of MMP- 3 and TIMP- 3 in 112 paraffin- em-bedded pathological specimens of NSCLC were determined by immunohistochemistry method. Al patients received plat-inum- based adjuvant chemotherapy after operation. The association of MMP- 3 and TIMP- 3 expression with response to chemotherapy and survival of patients were analyzed. Results Positive expression rates of MMP- 3 and TIMP- 3 were 56.25%and 47.32%in NSCLC patients, respectively. The survival time in MMP- 3 negative group was longer than that in MMP- 3 positive group(P<0.01) and in TIMP- 3 negative group was shorter than that in TIMP- 3 positive group(P<0.01). Patients with negative ex-pression of MMP- 3 and positive expression of TIMP- 3 showed a trend of improved survival time under platinum- based adjuvant chemotherapy. Conclusion The expression of MMP- 3 and TIMP- 3 is closely correlated with the survival time of NSCLC after ad-juvant chemotherapy, indicating that MMP- 3 and TIMP- 3 can be used as molecular makers for prognosis f NSCLC patients.