浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2013年
17期
1557-1560
,共4页
和肽素%脑出血%预后
和肽素%腦齣血%預後
화태소%뇌출혈%예후
Copeptin%Intracerebral hemorrhage%Prognosis
目的揭示血浆和肽素水平对脑出血（ICH）长期预后的预测价值。方法选取140例幕上ICH患者为ICH组，并以140例健康体检者作为对照组。采用ELISA法检测血浆和肽素水平。定义改良Rankin量表（mRS）＞2分为预后不良。统计分析血浆和肽素水平与ICH后3个月预后不良和死亡的关系。结果 ICH组血浆和肽素水平[（553.92±163.43）pg/ml]较对照组[（61.71±19.76）pg/ml]显著升高（P＜0.01）。ICH组血浆和肽素水平及血肿量与美国国立卫生院神经功能缺损评分呈显著正相关（r=0.547、0.561，均P＜0.01）。入院时血浆和肽素水平是ICH后3个月预后不良（OR=1.217,95%CI=1.097～3.476，P＜0.01）和死亡（OR=1.305，95%CI=1.113～3.953，P＜0.01）的独立危险因素。血浆和肽素水平可显著预测ICH后3个月预后不良（曲线下面积=0.860，95%CI=0.791～0.912，P＜0.01）和死亡（曲线下面积=0.863，95%CI=0.795～0.916，P＜0.01）。结论 ICH后升高的血浆和肽素水平与ICH后3个月临床预后密切相关。
目的揭示血漿和肽素水平對腦齣血（ICH）長期預後的預測價值。方法選取140例幕上ICH患者為ICH組，併以140例健康體檢者作為對照組。採用ELISA法檢測血漿和肽素水平。定義改良Rankin量錶（mRS）＞2分為預後不良。統計分析血漿和肽素水平與ICH後3箇月預後不良和死亡的關繫。結果 ICH組血漿和肽素水平[（553.92±163.43）pg/ml]較對照組[（61.71±19.76）pg/ml]顯著升高（P＜0.01）。ICH組血漿和肽素水平及血腫量與美國國立衛生院神經功能缺損評分呈顯著正相關（r=0.547、0.561，均P＜0.01）。入院時血漿和肽素水平是ICH後3箇月預後不良（OR=1.217,95%CI=1.097～3.476，P＜0.01）和死亡（OR=1.305，95%CI=1.113～3.953，P＜0.01）的獨立危險因素。血漿和肽素水平可顯著預測ICH後3箇月預後不良（麯線下麵積=0.860，95%CI=0.791～0.912，P＜0.01）和死亡（麯線下麵積=0.863，95%CI=0.795～0.916，P＜0.01）。結論 ICH後升高的血漿和肽素水平與ICH後3箇月臨床預後密切相關。
목적게시혈장화태소수평대뇌출혈（ICH）장기예후적예측개치。방법선취140례막상ICH환자위ICH조，병이140례건강체검자작위대조조。채용ELISA법검측혈장화태소수평。정의개량Rankin량표（mRS）＞2분위예후불량。통계분석혈장화태소수평여ICH후3개월예후불량화사망적관계。결과 ICH조혈장화태소수평[（553.92±163.43）pg/ml]교대조조[（61.71±19.76）pg/ml]현저승고（P＜0.01）。ICH조혈장화태소수평급혈종량여미국국립위생원신경공능결손평분정현저정상관（r=0.547、0.561，균P＜0.01）。입원시혈장화태소수평시ICH후3개월예후불량（OR=1.217,95%CI=1.097～3.476，P＜0.01）화사망（OR=1.305，95%CI=1.113～3.953，P＜0.01）적독립위험인소。혈장화태소수평가현저예측ICH후3개월예후불량（곡선하면적=0.860，95%CI=0.791～0.912，P＜0.01）화사망（곡선하면적=0.863，95%CI=0.795～0.916，P＜0.01）。결론 ICH후승고적혈장화태소수평여ICH후3개월림상예후밀절상관。
Objective To investigate the correlation of plasma copeptin levels with long- term prognosis of patients with intracerebral hemorrhage (ICH). Methods One hundred and forty patients with supratentorial ICH (ICH group) and 140 healthy subjects (control group) were recruited in the study. Plasma copeptin levels were determined using enzyme- linked immunosor-bent assay. Unfavorable outcome was defined as a modified Rankin Scale score>2. The correlation of plasma copeptin levels with 3- month unfavorable outcome and mortality was analyzed. Results Plasma copeptin levels were markedly higher in ICH group than those in control group [(553.92±163.43)pg/ml vs (61.71±19.76)pg/ml, P<0.01]. Plasma copeptin levels were posi-tively associated with hematoma volume (r=0.547, P<0.01) and National Institute of Health stroke scale score (r=0.561, P<0.01). Plasma copeptin level was an independent risk factor for 3- month unfavorable outcome (OR=1.217, 95%CI=1.097~3.476, P<0.01) and mortality (OR=1.305, 95%CI=1.113~3.953, P<0.01). The area under curve (AUC) of receiver operator characteristic curve (ROC) was 0.860 (95%CI=0.791~0.912, P<0.01) for plasma copeptin to predict unfavorable outcome and that was 0.863 (95%CI=0.795~0.916, P<0.01) for plasma copeptin to predict mortality of ICH patients. Conclusion Increased plasma copeptin levels after ICH are closely associated with 3- month prognosis of ICH patients.
