CAJ | 학술논문

目的探讨温州地区人群中ER-α基因MSPⅠ多态性与子宫内膜癌遗传易感性的关系。方法应用聚合酶链式反应-限制性片段长度多态性分析技术，对48例子宫内膜癌患者和96例健康体检者进行ER-α基因MSPⅠ多态性检测，并分析该基因多态性与子宫内膜癌发病风险的关系。结果 ER-α基因MSPⅠ多态性位点基因型频率及等位基因频率在子宫内膜癌组分别为TT（58.3%）、CC（10.4%）、TC（31.2%）；T（74.0%）、C（26.0%）；对照组分别为TT（31.2%）、CC（24.0%）、TC（44.8%）；T （53.6%）、C（46.4%），两组间比较均有统计学差异（均P＜0.05），且子宫内膜癌组等位基因C频率低于对照组（P＜0.01）。结论ER-α基因MSPⅠ位点多态性的存在可能与子宫内膜癌易感性有关，且ER-α基因野生型（TT）可能是子宫内膜癌的危险因素。
목적탐토온주지구인군중ER-α기인MSPⅠ다태성여자궁내막암유전역감성적관계。방법응용취합매련식반응-한제성편단장도다태성분석기술，대48례자궁내막암환자화96례건강체검자진행ER-α기인MSPⅠ다태성검측，병분석해기인다태성여자궁내막암발병풍험적관계。결과 ER-α기인MSPⅠ다태성위점기인형빈솔급등위기인빈솔재자궁내막암조분별위TT（58.3%）、CC（10.4%）、TC（31.2%）；T（74.0%）、C（26.0%）；대조조분별위TT（31.2%）、CC（24.0%）、TC（44.8%）；T （53.6%）、C（46.4%），량조간비교균유통계학차이（균P＜0.05），차자궁내막암조등위기인C빈솔저우대조조（P＜0.01）。결론ER-α기인MSPⅠ위점다태성적존재가능여자궁내막암역감성유관，차ER-α기인야생형（TT）가능시자궁내막암적위험인소。
Objective To assess the association of ER- α gene polymorphisms with endometrial cancer. Methods A case- control study was performed with 48 endometrial cancer patients and 96 matched controls. The ER- α- MSPⅠ polymor-phism sites were detected by using polymerase chain reaction- restriction fragment length polymorphism(PCR- RFLP). The asso-ciation between genotypes and endometrial cancer was estimated by odds ratios (ORs) and the 95% confidence intervals(CIs) calculated by unconditional logistic regression. Results The distribution frequency of genotype of ER- α- MSPⅠ site in en-dometrial cancer patients and controls was TT:58.3%and 31.2%, CC:10.4%and 24.0%, TC:31.2%and 44.8%, respectively;the frequency of al elic gene was T:74.0%and 53.6%, C:26.0%and 46.4%, respectively. There were significant differences in geno-type distributions between two groups (P<0.05), and the frequency of al elic C in endometrial cancer patients was lower than that of controls. Conclusion There may be association of ER- α- MSPⅠsite polymorphism with susceptibility of endometrial cancer.